Does metabolism in neurons act as an energy sensing mechanism linking hunger to the act of seeking food?

神经元的新陈代谢是否充当将饥饿与寻找食物的行为联系起来的能量感知机制？

• 批准号: nhmrc : GNT1072364
• 负责人: Dr Sarah Lockie
• 金额: $ 30.46万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-metabolism-neurons-seeking-food/1345040
• 关键词: Does; metabolism; neurons; act; energy

Obesity, and its associated pathologies, is a major disease concern. The brain systems that regulate food intake and body weight break down under the strain of obesity and this creates a vicious cycle where failure to regulate metabolism promotes further weight gain. I am investigating how the mitochondrial enzyme CPT1c regulates these brain systems, and whether obesity impairs CPT1c function. Understanding CPT1c function in the brain will help us understand the causes of obesity and diabetes.

肥胖及其相关病理是一个主要的疾病问题。调节食物摄入和体重的大脑系统在肥胖的压力下崩溃，这形成了一个恶性循环，新陈代谢的失败会导致体重进一步增加。我正在研究线粒体酶 CPT1c 如何调节这些大脑系统，以及肥胖是否会损害 CPT1c 功能。了解 CPT1c 在大脑中的功能将有助于我们了解肥胖和糖尿病的原因。