Does oxidation of lipoproteins by thiocyanate-derived oxidants produced by myeloperoxidase contribute to atherosclerosis

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Considerable evidence links the heme enzyme myeloperoxidase with atherosclerosis (hardening of the arteries), a disease that kills approximately 40% of Australians, and particularly people who smoke. The reasons for the elevated risk in smokers is not fully understood, though it is known that they have elevated thiocyanate levels - a major substrate for myeloperoxidase. The role of myeloperoxidase and thiocyanate in lipoprotein damage in atherosclerosis will be addressed in this project.