Does oxidation of lipoproteins by thiocyanate-derived oxidants produced by myeloperoxidase contribute to atherosclerosis

髓过氧化物酶产生的硫氰酸盐衍生氧化剂对脂蛋白的氧化是否会导致动脉粥样硬化

• 批准号: nhmrc : 570829
• 负责人: Prof Clare Hawkins
• 金额: $ 23.87万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-oxidation-lipoproteins-contribute-atherosclerosis/97770
• 关键词: Does; oxidation; lipoproteins; thiocyanate; derived

Considerable evidence links the heme enzyme myeloperoxidase with atherosclerosis (hardening of the arteries), a disease that kills approximately 40% of Australians, and particularly people who smoke. The reasons for the elevated risk in smokers is not fully understood, though it is known that they have elevated thiocyanate levels - a major substrate for myeloperoxidase. The role of myeloperoxidase and thiocyanate in lipoprotein damage in atherosclerosis will be addressed in this project.

大量证据表明血红素酶髓过氧化物酶与动脉粥样硬化（动脉硬化）有关，这种疾病导致大约40%的澳大利亚人死亡，特别是吸烟者。吸烟者风险升高的原因尚不完全清楚，尽管已知他们的硫氰酸盐水平升高-髓过氧化物酶的主要底物。髓过氧化物酶和硫氰酸盐在动脉粥样硬化脂蛋白损伤中的作用将在本项目中得到解决。