Investigating the link between oxidative stress and biomechanical integrin activation in diabetes

研究糖尿病中氧化应激与生物力学整合素激活之间的联系

• 批准号: nhmrc : 1127284
• 负责人: Prof Clare Hawkins
• 金额: $ 44.61万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-link-oxidative-activation-diabetes/947977
• 关键词: Investigating; link; between; oxidative; stress

Diabetes represents a serious healthcare problem globally. A large proportion of deaths associated with diabetes can be attributed to the development of blood clots in the circulation of the heart and brain (heart attack/stroke). The blood clotting mechanism is ‘hyperactive’ in diabetes, although the reason for this is not well defined. In this proposal we will investigate a new mechanism promoting blood clots, and will investigate innovative approaches to reduce this clotting mechanism.

糖尿病在全球范围内是一个严重的医疗保健问题。与糖尿病相关的大部分死亡可归因于心脏和大脑循环中血栓的发展（心脏病发作/中风）。糖尿病患者的凝血机制是“过度活跃”的，尽管其原因还没有很好的定义。在这项提案中，我们将研究一种促进血液凝块的新机制，并将研究减少这种凝血机制的创新方法。