DOSE-RELATED NEUROBEHAVIORAL EFFECTS OF CHRONIC COCAINE USE

本项目的目的是评估可卡因滥用个体的神经行为和神经心理表现。尽管可卡因的使用是一个重大的公共健康问题，但关于长期神经行为影响的科学数据很少。这项研究考察了长期使用可卡因与神经行为表现之间的剂量相关关系。对30名戒毒的慢性可卡因滥用者和21名年龄、教育程度和智力匹配的非药物对照组受试者进行了一系列神经心理测试。在控制了年龄、教育程度和智力后，更多地使用可卡因(每周克)与测量执行功能、视觉操作、精神运动速度和手动灵活性的测试中的较大降幅相关。这些结果表明，长期使用可卡因与认知功能的持续下降有关，这种下降在重度使用者中最为明显。了解慢性可卡因使用者的特定认知加工缺陷将有助于设计个性化的药物治疗计划。-大脑/药物效应、可卡因、神经心理测试、治疗-人类受试者：仅采访、问卷或调查

The purpose of this project is to assess the neurobehavioral and neuropsychological performance of cocaine abusing individuals. Although cocaine use is a significant public health problem, there is a paucity of scientific data on long-term neurobehavioral effects. This study examined the dose-related association between chronic cocaine use and neurobehavioral performance. A battery of neuropsychological tests was administered to 30 abstinent chronic cocaine abusers and 21 non- drug- using control subjects matched for age, education, and intelligence. After controlling for age, education, and intellectual ability, greater use of cocaine (grams per week) was associated with larger decrements on tests measuring executive functioning, visuoperception, psychomotor speed, and manual dexterity. These results suggest that chronic cocaine use is associated with persistent decrements in cognitive function that are most pronounced in heavy users. Knowledge of specific cognitive processing deficits in chronic cocaine users would be useful for designing individually tailored drug treatment programs. - Brain/drug effects, Cocaine, Neuropsychological Tests, Treatment - Human Subjects: Interview, Questionaires, or Surveys Only