RADIOLABELED MONOCLONAL ANTIBODY IMAGING OF TUMORS AND POSITRON EMISSION TOMOGRAP

肿瘤放射性标记单克隆抗体成像和正电子发射断层扫描

• 批准号: 6289424
• 负责人: JORGE A. CARRASQUILLO
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6289424
• 关键词: antitumor antibody; athymic mouse; carcinoma; clinical research; clinical trial phase I; colon neoplasms; combination cancer therapy; drug administration routes; human subject; immunoglobulin G; injection /infusion; longitudinal human study; monoclonal antibody; neoplasm /cancer immunotherapy; neoplasm /cancer radionuclide diagnosis; neoplasm /cancer radionuclide therapy; neoplasm /cancer relapse /recurrence; neoplasm /cancer transplantation; nuclear medicine; ovary neoplasms; peritoneal cavity; radiation therapy dosage; radionuclide imaging /scanning; radiopharmacology; rectum neoplasms; xenotransplantation; yttrium

These studies are designed to develop improved methods for detect-ing and treating malignancies. Our group performs preclinical evaluation of antibodies that appear to be promising after initial screening by various laboratories at the National Cancer Institute and develops these antibodies for clinical application. The clinical trials evaluating their pharmacokinetics and dosimetry are performed by our group. A collaborative radioimmunotherapy trial with Dr. Waldmann (Principal Investigator) in which we used humanized anti-tac monoclonal antibody, is ongoing. Imaging studies comparing the use of Tc-99m anti- CEA Fab (FDA approved) and F-18 deoxyglucose in patients with previous history of colorectal carcinoma and rising CEA with-out evidence of disease by conventional radiographic modalities are ongoing. We have characterized the fate of alpha emitting labeled antibody once modulation and internalization occur, as part of their preclinical evaluation. We have begun preliminary studies evaluating pretargeting of antibodies for tumor therapy.

这些研究旨在开发检测和治疗恶性肿瘤的改进方法。我们的小组在国家癌症研究所的各个实验室进行初步筛选后，对抗体进行临床前评估，并开发这些抗体用于临床应用。临床试验评价其药代动力学和剂量学是由我组完成的。与Waldmann博士（首席研究员）合作的放射免疫治疗试验正在进行中，我们使用人源抗tac单克隆抗体。目前正在进行影像学研究，比较Tc-99m抗CEA Fab （FDA批准）和F-18脱氧葡萄糖在有结直肠癌病史和CEA升高但没有常规影像学证据的患者中的应用。我们已经描述了α发射标记抗体一旦发生调节和内化的命运，作为其临床前评估的一部分。我们已经开始初步研究评估抗体在肿瘤治疗中的预靶向性。