Radiolabeled Monoclonal Antibody Imaging Of Tumors And P

肿瘤和肿瘤的放射性标记单克隆抗体成像

• 批准号: 7331893
• 负责人: JORGE A. CARRASQUILLO
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7331893
• 关键词: Radiolabeled; Monoclonal; Antibody; Imaging; Tumors

These antibody studies are designed to develop improved methods for detecting and treating malignancies. Our group performs preclinical evaluation of radiolabeled antibodies that appear to be promising after initial screening. The clinical trials evaluating their pharmacokinetics and dosimetry are performed by our group. One collaborative radioimmunotherapy trial with Dr. Waldmann (PI), in which we used humanized anti-tac monoclonal antibody,in patients with non ATL lymphomas is ongoing and with responses seen in numerours patients. Dr. Paik has focused his chemistry work including markers of angiogenesis. Various protocols using [F-18] FDG in PET and [O-15] water for tumor detection, followup, and blood flow measurements are ongoing with NCI. We continue work using FDG as a surrogate marker of resposne and disease status in a variety of malignacy. We continue to build on prior studies and are utilizing fluorodeoxyglucose PET in attemps to localize sites of activated lymphomcytes. We continue to evaluate the ability of FDG-PET to differentiate between patients with benign versus lymphomatous adenopathy in the setting of autoimmune lymphoprolifertive syndrome versus. We are collaborating within the Imaging science program and NIAID in evalauting new tracer to evaluate the pathogenesis of HIV infection in vitro.

这些抗体研究旨在开发用于检测和治疗恶性肿瘤的改进方法。我们的小组进行放射性标记抗体的临床前评价，初步筛选后似乎是有希望的。本课题组进行了药代动力学和剂量学的临床试验。与Waldmann博士（PI）合作进行的一项放射免疫治疗试验正在进行中，我们在非ATL淋巴瘤患者中使用了人源化抗tac单克隆抗体，并且在许多患者中观察到了反应。Paik博士专注于他的化学工作，包括血管生成的标志物。使用PET中的[F-18] FDG和[O-15]水进行肿瘤检测、随访和血流测量的各种方案正在与NCI一起进行。我们将继续使用FDG作为各种疾病的缓解和疾病状态的替代标志物。我们继续建立在以前的研究，并正在利用氟脱氧葡萄糖PET在pneumonia定位网站的活化淋巴细胞。我们将继续评估FDG-PET在自身免疫性淋巴增生综合征和淋巴结转移中区分良性和淋巴瘤性腺病的能力。我们正在与成像科学计划和NIAID合作评估新的示踪剂，以评估体外HIV感染的发病机制。

项目成果

F-18 fluorodeoxyglucose positron emission tomographic imaging in a patient with persistent hiccups.

持续打嗝患者的 F-18 氟脱氧葡萄糖正电子发射断层扫描成像。

• DOI: 10.1097/01.rlu.0000102762.66515.67
• 发表时间: 2004
• 期刊: Clinical nuclear medicine
• 影响因子: 10.6
• 作者: Nguyen,JohnD;Dunleavy,Kieron;Carrasquillo,JorgeA;Chen,ClaraC
• 通讯作者: Chen,ClaraC

Radioimmunotherapy of A431 xenografted mice with pretargeted B3 antibody-streptavidin and (90)Y-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin.

使用预靶向 B3 抗体-链霉亲和素和 (90)Y 标记的 1,4,7,10-四氮杂环十二烷-N,N,N",N"-四乙酸 (DOTA)-生物素对 A431 异种移植小鼠进行放射免疫治疗。

• 发表时间: 2002
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Yao,Zhengsheng;Zhang,Meili;Axworthy,DonaldB;Wong,KarenJ;Garmestani,Kayhan;Park,Luke;Park,ChangW;Mallett,RobertW;Theodore,LouisJ;Yau,EricK;Waldmann,ThomasA;Brechbiel,MartinW;Paik,ChangH;Pastan,Ira;Carrasquillo,JorgeA
• 通讯作者: Carrasquillo,JorgeA

Registration of planar emission images with reprojected CT data.

平面发射图像与重投影 CT 数据的配准。

• 发表时间: 2000
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Surova-Trojanova,H;Barker,WC;Carrasquillo,JA;Bacharach,SL
• 通讯作者: Bacharach,SL

Noninvasive estimation of the aorta input function for measurement of tumor blood flow with.

用于测量肿瘤血流量的主动脉输入函数的无创估计。

• DOI: 10.1109/42.918468
• 发表时间: 2001
• 期刊: IEEE transactions on medical imaging
• 影响因子: 10.6
• 作者: Watabe,H;Channing,MA;Riddell,C;Jousse,F;Libutti,SK;Carrasquillo,JA;Bacharach,SL;Carson,RE
• 通讯作者: Carson,RE

Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the alpha-emitting radionuclide, bismuth 213.

使用 α 发射放射性核素铋 213 对成人 T 细胞白血病小鼠模型进行预靶向放射免疫治疗。

• DOI: 10.1182/blood-2002-01-0107
• 发表时间: 2002
• 期刊: Blood
• 影响因子: 20.3
• 作者: Zhang,Meili;Yao,Zhengsheng;Garmestani,Kayhan;Axworthy,DonaldB;Zhang,Zhuo;Mallett,RobertW;Theodore,LouisJ;Goldman,CarolynK;Brechbiel,MartinW;Carrasquillo,JorgeA;Waldmann,ThomasA
• 通讯作者: Waldmann,ThomasA