Electromechanical Endocardial Mapping for Assessment of Myocardial Viability

一种新的左心室标测系统(Biosense，Inc.)使用低强度磁场能量来确定传感器尖端导管电极在LV内的位置。在以往实验和人体研究心肌缺血程度与电信号幅度相关的基础上，我们假设这种集成的LV机电标测系统可以根据心内膜电信号的幅度区分健康心肌和缺血或静止心肌。如果这一假设得到证实，在导管室中在线检测心肌存活和缺血的能力可能是可行的。本研究试图通过比较静息和药物刺激期间的左室电机械标测数据，以及使用MRI、PET、铊和ECHO的成像研究来区分缺血、静止和正常心肌。一旦这项技术被完善为左室内的指导工具，我们将开始利用这种输送系统进行激光血管重建和直接注射血管生成载体的研究。-心肌存活、缺血、正电子发射计算机断层扫描、核磁共振、心内膜机电标测-人类受试者

A novel left ventricular (LV) mapping system (Biosense, Inc.) uses low- intensity magnetic field energy to determine the location of sensor- tipped catheter electrodes within the LV. On the basis of previous experimental and human studies correlating the extent of myocardial ischemia with the amplitude of electrical signals, we hypothesize that such an integrated LV electromechanical mapping system could be used to distinguish healthy from ischemic or immobile myocardium on the basis of the extent of electromechanical endocardial signals. If this hypothesis is confirmed, the ability to detect on-line myocardial viability and ischemia in the catheterization laboratory may be feasible.The present study attempts to distinguish between ischemic, immobile, and normal myocardium by comparing LV electromechanical mapping data at rest and during pharmacologic stimulation, with imaging studies using MRI, PET, thallium and echo in patients with coronary artery disease.Once this technique is perfected as a guidance tool within the LV, we will embark on studies using this delivery system for laser revascularization and direct injection of angiogenic vectors. - Myocardial viability, ischemia, PET, MRI, electromechanical endocardial mapping - Human Subjects