CLINICAL RADIATION PHYSICS SERVICE

该科继续为放射治疗提供专业的物理和技术支持，包括日常校准，质量保证和所有辐射产生和辅助设备的一线维护。它包括特殊剂量学研究，计算机辅助治疗计划，病人监测和设计和开发专门的设备，以发展临床需要。二极管现在在常规临床应用中用于验证患者剂量，并显示出+/- 3的准确性。放射外科系统已安装并投入使用。到目前为止，我们已经成功治疗了25例立体定向放射手术患者，并计划利用可植入框架附着点从单段式放射手术过渡到多段式放射手术。与海军研究实验室合作评估半导体掺杂Vycor玻璃的临床应用的项目正在顺利进行。我们正在继续对剂量学性质进行表征，并利用这些数据来改进探测器的开发。临床试验预计于一九九九年初冬开始。迷你多叶准直器已经投入使用，不久将开始临床使用。目前正在进行的项目是一个精细的立体定向治疗计划系统的调试，该系统能够治疗更复杂的肿瘤体积，以及强度调制放射治疗（IMRT）的发展。顺序驱动的IMRT正在等待新的记录和验证系统的交付，该系统已经订购。在NCI建立IMRT研究计划将包括开发无框架立体定向定位系统。

The section continues to provide expert physical and technological support for radiation treatment, consisting of routine calibration, quality assurance and first-line maintenance of all radiation producing and ancillary equipment. It includes special dosimetry studies, computer- assisted treatment planning, patient monitoring and the design and development of special equipment tailored to developing clinical needs. Diodes are now in routine clinical use for the verification of patient doses and exhibit an accuract of +/- 3. The radiosurgery system has been installed and commissioned. To this date, we have successfully treated 25 stereotactic radiosurgery patients and plan to migrate from single fraction to multi fraction radiosurgery utilizing implantable frame attachment points. The project in collaboration with the Naval Research Laboratory to evaluate the clinical utility of semiconductor doped Vycor glass is well under way. We are continuing the characterization of the dosimetric properties and using these data to refine detector development. Clinical trials are expected to start by early Winter, 1999. The mini multileaf collimator has been commissioned and clinical use will commence shortly. Ongoing projects are the commisioning of a refined stereotactic treatment planning system capable of treating more complex tumor volumes and the development of intensity modulated radiation therapy (IMRT). Sequence driven IMRT is awaiting the delivery of a new Record-and Verify system, which has been ordered. The establishment of an IMRT research program at NCI will include the development of a frameless stereotactic localization system.