Wrist Flexion to Identify Carpal Tunnel Syndrome

手腕弯曲来识别腕管综合症

• 批准号: 6338065
• 负责人: ROBERT PERRY TUCKETT
• 金额: $ 10万
• 依托单位: NEUROSCIENCE RESEARCH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6338065
• 关键词: biomedical automation; biomedical equipment development; carpal tunnel syndrome; computer program /software; diagnosis design /evaluation; diagnosis quality /standard; early diagnosis; electrodes; electrophysiology; fingers; human subject; limb movement; nervous system disorder diagnosis; patient oriented research; sensory thresholds; wrist

DESCRIPTION (Applicant's Abstract): Although most health care practitioners would define carpal tunnel syndrome (CTS) as an entrapment, or compression, of the median nerve at the level of the wrist (e.g. carpal tunnel), the diagnosis is often not clear cut. A major reason for ambiguity is that in its initial stages, CTS often involves inflammation of tendons transversing the wrist that control finger movement and grip. As tendinitis progresses, there is a constellation of inflammatory events including swelling, vascular stasis, and nociceptor sensitization, which account for many of CTS clinical signs. Hence, clinical signs do not clearly differentiate between tendinitis and CIS, which requires direct testing of median nerve function specifically localized to the wrist area. At present, only conduction latency across the wrist fulfills these criteria. The alternative of sensory testing (e.g., two-point discrimination, monofilament or vibratory threshold) lacks specificity; that is, sensory deficits can be attributed to other causes. More recently, a provocative technique has provided evidence of wrist level, median nerve entrapment before symptoms become unequivocal by more traditional procedures, and has been reported to be specific for CTS over other forms of peripheral neuropathy. Topical Testing proposes to investigate ways of improving the efficiency of the initially reported provocative procedure to improve the specificity and sensitivity of CTS diagnosis. If feasibility criteria are satisfied, Phase II will propose an equipment package designed specifically for improved evaluation of carpal tunnel status. PROPOSED COMMERCIAL APPLICATION: Medical market segments for the treatment and rehabilitation of carpal tunnel syndrome include hand surgery, hand therapy, physical therapy, physiatry (PM&R), neurology, and occupational medicine. Potentially large markets for noninvasive instrumentation to screen for carpal tunnel injury include human resources, safety, ergonomics, and industrial hygiene.

描述(申请人摘要)：尽管大多数医疗从业者 将腕管综合征(CTS)定义为腕管压迫或压迫 正中神经在手腕水平(如腕管)，诊断 往往是不明确的。模棱两可的一个主要原因是，在它的最初 分期，CTS通常涉及横跨手腕的肌腱炎症， 控制手指的移动和握力。随着肌腱炎的进展，有一个 一系列炎症事件，包括肿胀、血管淤积和 伤害性感受器敏化，这是许多CTS临床症状的原因。因此， 临床体征不能明确区分肌腱炎和CIS， 需要专门定位于正中神经功能的直接测试 手腕部位。目前，只有手腕的传导潜伏期才能满足这些要求 标准。感觉测试的替代(例如，两点辨别， 单丝或振动阈值)缺乏特异性；即感觉 赤字可以归因于其他原因。 最近，一种挑衅性的技术提供了手腕水平的证据， 在症状变得明确之前正中神经卡压 程序，据报道是针对CTS的，而不是其他形式 周围神经病。局部测试建议调查方法 提高最初报告的挑衅程序的效率，以 提高CTS诊断的特异性和敏感性。如果可行 满足标准，第二阶段将提出设计的成套设备 专门用于改善腕管状态的评估。 建议的商业应用： 腕管治疗和康复的医疗市场细分 证候包括手部手术、手部治疗、理疗、理疗 (PM&R)、神经学和职业医学。潜在的巨大市场 无创器械筛查腕管损伤包括人类 资源、安全、人体工程学和工业卫生。

项目成果

Effects of prolonged wrist flexion on transmission of sensory information in carpal tunnel syndrome.

长时间腕部屈曲对腕管综合征感觉信息传递的影响。

• DOI: 10.1016/j.jpain.2006.06.009
• 发表时间: 2007
• 期刊: The journal of pain : official journal of the American Pain Society
• 作者: Sesek,RichardF;Khalighi,Mehdi;Bloswick,DonaldS;Anderson,Mark;Tuckett,RobertP
• 通讯作者: Tuckett,RobertP