VIBROMETER FOR ANIMAL TESTING

描述：(摘自申请者的摘要)一个传统的量化 周围神经病的动物试验包括测量动物的 伤害性热刺激的行为阈值。这一点的局限性 方法是热激活的感觉种群在很大程度上是 无髓鞘；因此，与直接电生理记录的相关性是 难度极大，耗时极长。或者，单丝测试 手持探头提供了大范围的感觉阈值排名 机械感觉轴突，相对容易记录和识别 组织学上。此外，最近的证据支持这样一个概念： 机械感受器感觉通路参与传递慢性疼痛的信号。这个 开发一种比定量更多的刺激程序 单丝测试将有助于外周血肿的行为研究 感觉神经病(如糖尿病、烧伤、压迫和艾滋病)，以及 开发治疗慢性疼痛的新药以及基础药物 遗传学和神经生物学方面的研究。神经科学研究提出 具有标准程序和标准的商业开发模式系统 用于量化动物模型中机械感觉相关神经病变的仪器。 第一阶段将在周围神经病的动物模型上测试系统的可行性 表现出机械性异位痛觉(机械性诱发阈值降低 疼痛)。 建议的商业应用： 用于量化动物周围神经病的仪器市场包括许多基本的 和应用研究实验室；例如，那些涉及遗传、神经科学和 外周神经发育和功能的神经生物学研究；药物 公司筛选治疗急性和慢性疼痛的化合物，以及 神经毒性；以及研究周围神经病变的实验室(例如，艾滋病、糖尿病、 压迫、化学神经毒理学)。

DESCRIPTION: (From the applicant's Abstract) One traditional quantitative animal assay for peripheral neuropathy involves measuring the animal's behavioral threshold to noxious thermal stimulation. A limitation of this approach is that thermally activated sensory populations are for the most part unmyelinated; hence, correlation with direct electrophysiological recording is extremely difficult and time-consuming. Alternatively, monofilament testing with hand-held probes provides a ranking of sensory threshold in large mechanosensory axons, which are relatively easy to record and identify histologically. In addition, recent evidence supports the concept that mechanoreceptor sensory pathways are involved in signaling chronic pain. The development of a stimulation procedure that is more quantitative than monofilament testing would be of benefit in behavioral studies of peripheral sensory neuropathy (e.g., diabetes, burn injury, compression, and AIDS), and development of new drugs for treatment of chronic pain, as well as basic investigations in genetics and neurobiology. Neuroscience research proposes the commercial development model system with standard procedures and instrumentation to quantify mechanosensory-related neuropathy in animal models. Phase I will test system feasibility in animal models of peripheral neuropathy that exhibit mechanical allodynia (diminished threshold to mechanically induced pain). PROPOSED COMMERCIAL APPLICATION: Markets for instrumentation to quantify animal peripheral neuropathy include numerous basic and applied research laboratories; e.g., those involved in genetic, neuroscience, and neurobiological studies of peripheral neural development and function; pharmaceutical companies screening for compounds to treat acute and chromic pain, as well as neurotoxicity; and laboratories studying peripheral neuropathy (e.g., AIDS, diabetic, compression, chemical neurotoxicology).