Bioabsorbable Polymer-Based Nerve Conduits

生物可吸收聚合物神经导管

• 批准号: 6338044
• 负责人: Donald Hayes
• 金额: $ 10万
• 依托单位: MICROFAB TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-27 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6338044
• 关键词: biodegradable product; bioengineering /biomedical engineering; biomaterial development /preparation; biotechnology; innervation; nerve growth factors; nervous system regeneration; neural conduction; polymers; tissue /cell culture; tissue support frame

DESCRIPTION: We will construct bifurcated (Y-shaped), three-dimensional, biologically active and bioabsorbable polymer-based nerve conduits using ink-jet microdispensing technology for the purpose of facilitating peripheral nerve repair through methods of tissue engineering. These bifurcated, polymer-based nerve conduits will be created under a digitally controlled ink-jet platform to assure direct control of conduit dimensions and construction of B-Nerve Growth Factor (B-NGF) gradients in order to demonstrate selective neurite outgrowth from PC-12 cells based on the abundance of conduit ligated B-NGF in a three-dimensional space. By applying our ink-jet technology we will be able to fabricate nerve conduits containing biomolecule step-gradients that will ultimately enable tissue engineers to selectively control the pathways neurites take to different target areas, and eliminate current barriers associated with current nerve guidance conduits such as non-specific target reinervation. When compared with current mold-based conduit fabrication, ink-jet technology based printing offers a degree of selectivity, specificity, and micro-material deposition otherwise unavailable. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

我们将构建分叉（Y形），三维， 生物活性和生物可吸收的聚合物基神经导管 喷墨微点胶技术， 通过组织工程的方法修复神经。这些分叉的， 基于聚合物的神经导管将在数字控制下创建， 喷墨平台，以确保直接控制导管尺寸， 构建B-神经生长因子（B-NGF）梯度，以证明 基于导管丰度的PC-12细胞的选择性神经突生长 在三维空间中连接B-NGF。通过应用我们的喷墨技术 我们就能制造出含有生物分子的神经导管 阶梯梯度，最终使组织工程师能够选择性地 控制神经突起到达不同目标区域的路径， 与当前神经引导导管相关联的电流屏障 非特异性靶神经再支配与现有的基于模具的导管相比 制造，基于喷墨技术的印刷提供了一定程度的选择性， 特异性和微材料沉积，否则不可用。 拟议商业应用：不可用