Two Coil Arterial Spin Labeling Cerebral Perfusion MRI

两线圈动脉旋转标记脑灌注 MRI

• 批准号: 6337182
• 负责人: PATRICK J LEDDEN
• 金额: $ 9.5万
• 依托单位: NOVA MEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6337182
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; blood flow measurement; brain circulation; brain disorder diagnosis; brain mapping; cerebrum; clinical research; human subject; magnetic resonance imaging; neuroimaging; noninvasive diagnosis; technology /technique development

DESCRIPTION (Provided by Applicant): Cerebral blood flow (CBF) defines the rate of delivery of metabolic substrates and is central to brain metabolism. A non-invasive method for measuring regional cerebral blood flow is therefore important for assessing pathologies associated with alterations in cerebral metabolism such as carotid artery stenosis, stroke, and brain tumors, as well as for studying mental illnesses and drug abuse. In this study we will develop and assess the feasibility of a novel MR hardware for regional CBF and perfusion territory mapping in humans. The novel Arterial Spin Labeling (ASL) technique for cerebral perfusion and perfusion territory mapping proposed will build on our preliminary MR continuous Arterial Spin Labeling (cASL) work which has provided the first system capable of performing cASL in humans at 3T. To achieve this, we will validate the feasibility of a method employing a separately gated OW AF source that can be flexibly interfaced to GE or Siemens scanners and an independently detunable spin-labeling coil to magnetically label inflowing blood water for use in conjunction with a detunable head coil to eliminate interactions between the imaging and labeling systems. The proposed system will improve the MR perfusion measurements by: 1) Providing a magnetization transfer-free technique allowing the acquisition of multi-slice, arbitrary plane, quantitative MR perfusion maps. 2) Improving sensitivity and coverage by covering all of the major arteries with an efficient labeling coil, thus enabling a multi-coil cASL method that will label both posterior and anterior circulation at 3T. Continuous ASL methods has previously been limited to 1 .5T by potentially unsafe RF power demands. 3) Independently labeling each of the carotid arteries to allow the mapping of their perfusion territory and assessing collateral flow. PROPOSED COMMERCIAL APPLICATION: Cerebral perfusion measurements by MRI are a relatively new but rapidly growing method for studying a wide range of disorders that alter local or global cerebral blood flow. We plan to make the two coil arterial spin labeling system available for the first time, to the over 200 neuroimaging research sites. We plan to pursue a clinical product based on the success of the "investigational use only" device.

描述(申请人提供)：脑血流量(CBF)定义心率 代谢底物的传递，是大脑新陈代谢的中心。一个 因此，无创测量局部脑血流量的方法 对于评估与脑部改变相关的病理很重要 代谢，如颈动脉狭窄、中风和脑肿瘤 至于研究精神疾病和药物滥用。在这项研究中，我们将开发 并评估了一种新的磁共振硬件用于区域性CBF和 人体内的灌注区标测。 动脉自旋标记(ASL)脑血流灌注成像新技术 建议的灌注区域标测将建立在我们初步的MR基础上 连续动脉自旋标记(CASL)工作提供了第一个 能够在3T时在人体内执行CASL的系统。为了实现这一目标，我们将 验证使用单独选通的OW AF源的方法的可行性 它可以灵活地与GE或西门子扫描仪接口，并独立 可调谐自旋标记线圈对流入的血液水进行磁性标记 与可调谐磁头线圈一起使用，以消除 成像和标签系统。建议的系统将改善MR 血流灌注测量：1)提供无磁化转移技术 允许获取多层、任意平面、定量的MR 血流灌注图。2)通过覆盖所有 具有高效标记线圈的主要动脉，从而实现多线圈CASL 在3T时标记后循环和前循环的方法。 连续的ASL方法以前被限制在1.5T以内，因为潜在地 不安全的射频功率需求。3)独立标记每条颈动脉 以便绘制他们的灌注区并评估侧支循环 流。 建议的商业应用： 核磁共振脑血流灌注测量是一项相对较新但发展迅速的技术 研究改变局部或整体大脑的广泛疾病的方法 血液流动。我们计划推出双线圈动脉自旋标记系统 第一次，向200多个神经成像研究站点开放。我们计划追查 这是一种基于“仅供研究使用”设备的成功的临床产品。