Does remote ischemic preconditioning induce protective mitochondrial function in congenital heart defect repair surgery?

远程缺血预处理是否会在先天性心脏缺陷修复手术中诱导保护性线粒体功能？

• 批准号: nhmrc : 607404
• 负责人: A/Pr Michael Cheung
• 金额: $ 9.52万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-remote-ischemic-repair-surgery/81389
• 关键词: Does; remote; ischemic; preconditioning; induce

The body's own protective mechanism against injury due to reduced blood flow (ischemic preconditioning) has been studied for over 2 decades, yet the clinical benefits have not been realised until recently . We have previously shown that this innate protection can be induced without drugs in children having heart surgery. We will extend these findings to determine the mechanism of protection, develop a method to monitor this in blood cells and see if this is related to post-operative outcomes.

人体自身的保护机制，防止因血流减少（缺血预处理）造成的损伤，已经研究了20多年，但直到最近才实现临床益处。我们以前已经证明，这种先天性保护可以在没有药物的情况下诱导心脏手术的儿童。我们将扩展这些发现，以确定保护机制，开发一种方法来监测血细胞中的保护作用，并看看这是否与术后结果有关。