Identification of a plasma factor of remote ischemic preconditioning and its effect on the proteome after heart surgery

远程缺血预处理血浆因子的鉴定及其对心脏术后蛋白质组的影响

• 批准号: nhmrc : 628756
• 负责人: A/Pr Michael Cheung
• 金额: $ 25.68万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-plasma-factor-heart-surgery/76965
• 关键词: Identification; plasma; factor; remote; ischemic

Heart surgery with the heart placed into arrest causes inflammation and tissue damage due to interrupted circulation. We know that prior brief interruption and restoration of blood supply called remote ischemic preconditioning (IPC) can protect heart and lungs against damage. Our previous studies indicate that IPC involves a circulating factor that protects the tissue by optimizing energy preservation. This knowledge can be applied to organ transplants, protection from stroke and heart attack.

心脏手术中心脏停搏会导致炎症和组织损伤，因为循环中断。我们知道，预先短暂中断和恢复血液供应称为远程缺血预处理（IPC）可以保护心脏和肺免受损害。我们以前的研究表明，IPC涉及通过优化能量保存来保护组织的循环因子。这些知识可以应用于器官移植，预防中风和心脏病发作。