System to Eliminate and Prevent Biofilms in Dental Units

描述：有大量证据表明， 微生物起源于生长在牙科水管线内的生物膜 这些单位作为感染源构成重大风险。的当前方法 解决这一问题的方法效果有限。这里提出的项目 将导致适合与任何牙科单元一起使用的系统的开发 这将抑制微生物的生长以保持流出物中的微生物负荷 低于ADA推荐水平200 cfu/mL的水，并逐渐消除任何 现有的生物膜，最小的用户干预和无消耗品。的 所提出的系统使用光催化电池的组合来去除有机物 和定期冲洗水管， 过氧化氢，按需产生，以消除 水线拟议的项目将使每个单独的组成部分， 整合到一个统一的台式系统中，并展示 该系统，特别是新的使用点过氧化氢， 合成细胞，通过使用抑制，并最终根除，生物膜 存在于使用过的牙科单元中。该项目将导致设计一个 适用于临床试验的原型装置。 拟定商业应用： 美国大约有20万名牙医，平均每人有2个牙科治疗台， 共计40万个牙科诊所。 满足ADA建议将需要改造 几乎所有的牙科综合治疗台都有清洁的水系统， 与净水系统一起出售的单位。 该项目的产品将是一个干净的 水系统，可以添加到任何型号的牙科综合治疗台，使牙科综合治疗台 遵守。 在500美元/台的情况下，这是美国潜在的2亿美元的改造市场， 在全球范围内具有额外的潜力，并在新安装的持续销售中。

DESCRIPTION: There is a substantial body of evidence demonstrating that microorganisms originating in biofilms growing inside the water lines of Dental units pose a significant risk as a source of infection. Current methods for countering this problem are of limited effectiveness. The project proposed here will lead to the development of a system suitable for use with any Dental unit that will suppress microbial growth to keep the microbial load in the effluent water below the ADA recommended level of 200 cfu/mL and gradually eradicate any existing biofilm with minimal user intervention and no consumables. The proposed system uses a combination of a photocatalytic cell to remove organisms from the incoming water stream and periodic flushing of the water line with hydrogen peroxide, generated on demand to eliminate any organisms within the water line. The proposed project will bring each of the individual components together into one unified bench-top system and demonstrate the effectiveness of that system, and particularly the novel point-of-use hydrogen peroxide synthesis cell, by using the to suppress, and eventually eradicate, the biofilm present in a used Dental unit. This project will lead to the design of a prototype unit suitable for clinical testing. PROPOSED COMMERCIAL APPLICATION: There are roughly 200,000 dentists in the U.S., with an average of 2 dental units each for a total of 400,000 dental units. Meeting ADA recommendations will require retrofitting nearly all of the dental units with a clean water system, as well as equipping all new units sold with clean water systems. The product of the proposed project will be a clean water system that can be added onto any model of dental unit, bringing that dental unit into compliance. At $500/unit, this is a potential of $200,000,000 retrofit market in the U.S., with an additional potential around the world and in continuing sales for new installations.