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PHYSIOLOGICAL CONTROLLER FOR ROTARY BLOOD PUMPS

旋转式血泵的生理控制器

基本信息

批准号：
6292387
负责人：
HENRY A KOSZARSKY
金额：
$ 9.85万
依托单位：
ANTAKAMATICS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-07-15 至 2002-06-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6292387
关键词：
artificial intelligence auxiliary heart prosthesis biomedical device power system biomedical equipment development cardiac output circulatory assist computer system design /evaluation electrophysiology microprocessor /microchip

项目摘要

DESCRIPTION (Verbatim From Applicant's Abstract): As the prospects of a mechanical replacement for a failing human heart are fast becoming a reality, and patients are indeed returning home to regain a "normal" lifestyle, the limitations of this technology upon quality of life are becoming more apparent. To address many of these limitations, investigators are developing next-generation ventricular assist devices. Based on turbopump technology, these new devices offer smaller size, greater efficiency (hence smaller batteries), high reliability, and are more cost effective as compared to their pulsatile predecessessors. For all the virtues of these new turbopumps, they bring with additional challenges. Arguably the most urgent is the need for added intelligence." These, relatively stupid, devices are highly dependent on feedback-control to provide physiological response. Unfortunately, developers have yet to wage a systematic assault on this problem. Preoccupied with apparently more urgent issues, such as biocompatibility etc., there has been relatively little attention or resources directed at developing a physiological controller. For the past eight years, the P.I. has had an interest in this problem, and has conducted basic and applied research towards developing control algorithms. He now proposes to devise a general-purpose controller product, which can be incorporated into a variety of rotary pump systems for clinical use. The goal of the Phase-I effort proposed herein are to design a robust control algorithm which may then be implemented, in Phase-Il, into an applications specific integrated circuit. The P.I. envisions that this chip would be made available to device developers much like control circuits produced by Intel, Motorola, Texas Instruments, etc., are adopted by a wide variety of users for their specific products. PROPOSED COMMERCIAL APPLICATION: Direct application to virtually all rotary-type blood pumps for critical care and chronic use. The P.I. envisions that the Antakamatics control chip would be made available to device developers much like integrated circuits producted by Intel, Motorola, Texas Instruments, etc. are adopted by a wide variety of users for their specific products. The market for this product is estimated to exceed 200,000 units per annum, and there currently exists no competing product.

描述（来自申请人的摘要的逐字）：用机械代替衰竭的人类心脏正在迅速成为现实，病人确实回家恢复“正常”的生活方式，这种技术对生活质量的限制正变得越来越明显。为了解决这些限制，研究人员正在开发下一代心室辅助装置基于涡轮泵技术，这些新设备提供更小的尺寸、更高的效率（因此更小电池），高可靠性，并且与它们相比更具成本效益。搏动性心脏起搏器尽管这些新型涡轮泵有种种优点，带来额外的挑战。可以说，最紧迫的是需要增加了智慧。“这些相对愚蠢的设备高度依赖于反馈控制以提供生理反应。不幸的是，开发商还没有对这个问题进行系统的攻击。全神贯注于显然更紧迫的问题，如生物相容性等，出现相对较少的注意力或资源用于发展生理学 controller. 在过去的八年里，私家侦探。对这个问题很感兴趣，进行了开发控制算法的基础和应用研究。他现在提出设计一种通用控制器产品，结合到用于临床使用的各种旋转泵系统中。本文提出的第一阶段工作的目标是设计一个鲁棒控制算法，然后可以在阶段II中实现到应用程序中，特定集成电路。私家侦探设想这个芯片提供给设备开发者，就像英特尔、摩托罗拉、德州仪器等，被各种各样的用户的具体产品。拟定商业应用：可直接应用于几乎所有用于重症监护和长期使用的旋转式血泵。私家侦探设想Antakamatics控制芯片将提供给设备，开发商非常喜欢英特尔，摩托罗拉，德州仪器，等被广泛的用户用于他们的特定产品。市场该产品估计每年超过200，000个单位，并且目前存在没有竞争产品。