NANOELECTRODE ENSEMBLES FOR NEUROCHEMICAL ANALYSIS

描述：提出了用于神经化学分析的纳米电极集合。 所提出的神经化学探针可以提供高性能的测量 神经化学物种，可以帮助减轻人类疾病的负担， 脑神经系统功能障碍的原因，并了解每一个这些 元素以及它们之间的相互关系。 电化学伏安法已经显示出用于直接测量 神经系统中的各种神经化学物质，然而，现有的 单探针微电极具有不适用于高 性能伏安测量。该计划旨在开发纳米 规模电极合奏，明显更快，更敏感， 比现有的微电极更可靠。一种新的模板合成方法 将用于制备纳米电极集合体，创新将集中在 电极结构的纳米工程可以提供以下优点： 工程纳米结构。预计拟议的纳米电极系综 具有显著增强的界面扩散率和降低的 双层电容实现高速测量和低检测 限制和高选择性。 在第一阶段，AMSEN Technologies将展示以下概念验证： 这种电极集合。拟议的创新可能非常有用， 神经化学分析在应用中，敏感，选择性，快速， 需要对神经递质进行高度定位的检测和监测。 拟议商业应用：不可用

DESCRIPTION: Nanoelectrode ensembles for neurochemical analysis are proposed. The proposed neurochemical probe can provide high performance measurements of neurochemical species that can help to reduce the burden of human illness and dysfunction from brain neuro-system causes and to understand each of these elements and how they interrelate. Electrochemical voltammetry has shown great promise for direct measurements of a variety of neurochemical species in neurosystems, however, the existing single probe microelectrodes have limitations that are not suitable for high performance voltammetric measurements. This program seeks to develop nano-meter scale electrode ensembles that are significantly faster, more sensitive, and reliable than existing microelectrodes. A novel template synthesis approach will be used to prepare nanoelectrode ensembles, and the innovation will focus on nano-engineering of the electrode structure that can provide advantages from the engineered nanostructure. The proposed nanoelectrode ensembles are expected to have significantly enhanced interfacial diffusivities and reduced double-layer capacitance enabling high speed measurements with low detection limits and high selectivity. During Phase I, AMSEN Technologies will demonstrate the proof-of-concept of such an electrode ensemble. The proposed innovation can be extremely useful for neurochemical analysis in applications where sensitive, selective, fast, and highly localized detection and monitoring of neurotransmitters are needed. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE