NANOELECTRODE ENSEMBLES FOR NEUROCHEMICAL ANALYSIS

描述：提出了用于神经化学分析的纳米电极系综。 建议的神经化学探针可以提供高性能的测量 神经化学物种可以帮助减轻人类疾病的负担和 脑神经系统功能障碍的原因及其各自的理解 元素以及它们之间的相互关系。 电化学伏安法在直接测量苯系物方面显示出巨大的前景。 然而，神经系统中的各种神经化学物种，现有的 单探针微电极具有不适用于高密度的限制 性能伏安测量。该计划旨在发展纳米技术 刻度电极组合显著更快、更灵敏和 比现有的微电极更可靠。一种新的模板合成方法 将用于制备纳米电极系综，创新将集中于 关于电极结构的纳米工程 这种经过改造的纳米结构。提出的纳米电极系综可望 极大地提高了界面扩散系数并降低了 双层电容，可实现低检测的高速测量 极限和高选择性。 在第一阶段，AMSEN Technologies将演示 这样的电极组。建议的创新对以下方面非常有用 神经化学分析在以下应用中敏感、选择性、快速和 需要对神经递质进行高度本地化的检测和监测。 建议的商业应用：不可用

DESCRIPTION: Nanoelectrode ensembles for neurochemical analysis are proposed. The proposed neurochemical probe can provide high performance measurements of neurochemical species that can help to reduce the burden of human illness and dysfunction from brain neuro-system causes and to understand each of these elements and how they interrelate. Electrochemical voltammetry has shown great promise for direct measurements of a variety of neurochemical species in neurosystems, however, the existing single probe microelectrodes have limitations that are not suitable for high performance voltammetric measurements. This program seeks to develop nano-meter scale electrode ensembles that are significantly faster, more sensitive, and reliable than existing microelectrodes. A novel template synthesis approach will be used to prepare nanoelectrode ensembles, and the innovation will focus on nano-engineering of the electrode structure that can provide advantages from the engineered nanostructure. The proposed nanoelectrode ensembles are expected to have significantly enhanced interfacial diffusivities and reduced double-layer capacitance enabling high speed measurements with low detection limits and high selectivity. During Phase I, AMSEN Technologies will demonstrate the proof-of-concept of such an electrode ensemble. The proposed innovation can be extremely useful for neurochemical analysis in applications where sensitive, selective, fast, and highly localized detection and monitoring of neurotransmitters are needed. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE