THERMOPLASTIC POLYURETHANE WITH ENHANCED BIOSTABILITY

具有增强生物稳定性的热塑性聚氨酯

• 批准号: 6298647
• 负责人: Alan M Zamore
• 金额: $ 10万
• 依托单位: ZYLON CORPORATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6298647
• 关键词: biomaterial compatibility; biomaterial development /preparation; chemical stability; chemical synthesis; crosslink; electrical conductance; electron radiation; electronic pacemaker; implant; polyurethanes; technology /technique development

DESCRIPTION (Verbatim From Applicant's Abstract): Our novel and innovative approach for improving the biostability of thermoplastic polyurethane Consists of chemically modifying tpu and crosslinking it with electron beam radiation. The objective of this Phase I proposal is to evaluate, using a combination of in vivo and in vitro studies, the degree to which this innovative approach improves the biostability of TPU. An improvement in the blostability of TPU would have wide application in biomedical devices especially in Cardiac Pacemakers. Cardiac pacemakers are medical devices, which regulate cardiac rhythmic disorders. Pacemakers comprise a generator, connected to an insulated lead, which is implanted in the heart. Electrical pulses transmitted via the lead are timed to stimulate the heart muscle in a regulated manner. Pacemaker failures may result from deterioration of the pacemaker lead wire insulation. A tailed lead must be surgically replaced. The availability of a cardiac pacemaker wire insulation with increased implant lifetime would be of great value to the medical profession, Such improved leads would eliminate or greatly reduce the requirement for costly and risky surgical lead replacement procedures. A successful demonstration of increased biostability of cross-linked tpu would encourage commercialization of pacemakers utilizing crosslinked tpu insulated leads. PROPOSED COMMERCIAL APPLICATION: Potential commercial applications include pacemaker leads, Vascular grafts, Artifical hearts, Neurological leads, Arterio-venous dialysis shunts, Implantable defibrillators, Wound dressings, Cardiac catheter, Urethral catheters Mammary prostheses, IV bags and tubing, Chemotherapy tubing, Joint protheses, Cardiac valves, and cardiac assist devices such as aortic balloon pumps.

描述（来自申请人的摘要的逐字）： 用于改善热塑性聚氨酯的生物稳定性的方法 化学改性TPU并用电子束辐射交联。 第一阶段提案的目标是， 在体内和体外研究中，这种创新方法 提高了TPU的生物稳定性。 改善TPU的起泡性将在以下方面具有广泛的应用： 生物医学设备，特别是心脏起搏器。 心脏起搏器是一种调节心脏节律的医疗器械 紊乱起搏器包括连接到绝缘导线的发生器， 植入心脏通过电极导线传输的电脉冲 定时刺激心脏肌肉以调节的方式。起搏器故障 可能是由于起搏器导线绝缘的劣化。加尾 必须通过手术更换导线。心脏起搏器导线的可用性 具有增加的注入寿命的绝缘将对 这种改进的铅将消除或大大减少 需要昂贵且有风险的外科电极导线更换程序。 成功证明交联TPU的生物稳定性增加， 鼓励使用交联TPU绝缘的起搏器的商业化 线索. 拟定商业应用： 潜在的商业应用包括起搏器引线、血管移植物、心脏移植物， 神经电极导线、动静脉透析分流器、植入式除颤器、伤口敷料， 心脏导管、尿道导管、乳房假体、静脉输液袋和输液管、化疗 管道、关节假体、心脏瓣膜和心脏辅助装置，例如主动脉球囊 泵.