THERMOPLASTIC POLYURETHANE WITH ENHANCED BIOSTABILITY

描述(逐字摘自申请者摘要)：我们的新颖和创新 提高热塑性聚氨酯生物稳定性的途径 对TPU进行化学修饰，并用电子束辐射使其交联。 此第一阶段提案的目标是使用以下各项的组合进行评估 在体内和体外研究，这种创新的方法在多大程度上 提高了TPU的生物稳定性。 改善热塑性弹性体的溶胀性将在 生物医学设备，特别是心脏起搏器。 心脏起搏器是调节心律失常的医疗器械。 精神错乱。起搏器包括发电机，其连接到绝缘导线， 它被植入心脏。通过导线传输的电脉冲 定时以有规律的方式刺激心肌。起搏器故障 可能是起搏器导线绝缘劣化所致。尾巴 铅必须通过手术更换。心脏起搏器钢丝的可用性 延长植入物寿命的绝缘材料将对 这种改进的引线将消除或大大减少 对昂贵和危险的外科导线更换程序的要求。 若能成功证明交联型热塑性聚氨酯的生物稳定性提高， 鼓励使用交联型热塑性聚氨酯绝缘起搏器的商业化 线索。 建议的商业应用： 潜在的商业应用包括起搏器导线、血管移植物、人工心脏、 神经导联，动静脉透析分流术，植入式除颤器，伤口敷料， 心脏导管、导尿管、乳房假体、静脉输液袋和导管、化疗 管子、关节假体、心脏瓣膜和心脏辅助设备，如主动脉球囊 打气筒。

DESCRIPTION (Verbatim From Applicant's Abstract): Our novel and innovative approach for improving the biostability of thermoplastic polyurethane Consists of chemically modifying tpu and crosslinking it with electron beam radiation. The objective of this Phase I proposal is to evaluate, using a combination of in vivo and in vitro studies, the degree to which this innovative approach improves the biostability of TPU. An improvement in the blostability of TPU would have wide application in biomedical devices especially in Cardiac Pacemakers. Cardiac pacemakers are medical devices, which regulate cardiac rhythmic disorders. Pacemakers comprise a generator, connected to an insulated lead, which is implanted in the heart. Electrical pulses transmitted via the lead are timed to stimulate the heart muscle in a regulated manner. Pacemaker failures may result from deterioration of the pacemaker lead wire insulation. A tailed lead must be surgically replaced. The availability of a cardiac pacemaker wire insulation with increased implant lifetime would be of great value to the medical profession, Such improved leads would eliminate or greatly reduce the requirement for costly and risky surgical lead replacement procedures. A successful demonstration of increased biostability of cross-linked tpu would encourage commercialization of pacemakers utilizing crosslinked tpu insulated leads. PROPOSED COMMERCIAL APPLICATION: Potential commercial applications include pacemaker leads, Vascular grafts, Artifical hearts, Neurological leads, Arterio-venous dialysis shunts, Implantable defibrillators, Wound dressings, Cardiac catheter, Urethral catheters Mammary prostheses, IV bags and tubing, Chemotherapy tubing, Joint protheses, Cardiac valves, and cardiac assist devices such as aortic balloon pumps.