CRYSTAL SIZE AND SHAPE MEASUREMENT FOR INSITU MONITORING

用于原位监测的晶体尺寸和形状测量

• 批准号: 6310839
• 负责人: DONALD HOLVE
• 金额: $ 9.85万
• 依托单位: PROCESS METRIX, LLC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2001-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6310839
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; crystallization; digital imaging; measurement; molecular shape; molecular size; monitoring device; morphology

DESCRIPTION:(Applicant's description) The long-term objective of this research is to provide an instrument for in-situ measurement of crystal size and shape so as to control and optimize pharmaceutical crystallization processes. This instrument will also be useful for research on fabrication of new crystals, especially fragile crystals. In Phase I, the investigators plan to build a prototype and test it with pharmaceutical crystals. The proposed instrument is based on laser illumination and digital imaging. The first challenge is to obtain quantitative information about crystal size and shape (imaging based techniques are generally not reliable for quantitative measurements). The investigators' approach involves using a small field of view, so as to observe a single crystal at a time. A sensor will be used to indicate the presence of a crystal in the field of view. The digital images of single crystals will be processed using a novel line integration method to obtain accurate quantitative results. Another challenge is to acquire and process data at a high enough rate to enable process control. This will be accomplished by utilizing the latest imaging technology developed for machine vision. Finally, the optical design of the instrument will account for the fact that typical crystallizers have limited viewing access. PROPOSED COMMERCIAL APPLICATION: The successful completion of Phase II will lead to a very desirable instrument for in-situ measurement of crystal size and shape during the crystal growth process. These measurements will help the user control and fine-tune the process parameters. Both size and shape are known to have a strong impact on the mechanical and thermodynamic properties of crystals as well as inclusion of liquid and impurities in the crystals.

描述：（申请人描述）本研究的长期目标 是提供一种用于原位测量晶体尺寸和形状仪器 从而控制和优化药物结晶过程。这 仪器也将用于研究新晶体制造， 尤其是易碎的晶体。在第一阶段，研究人员计划建立一个 制作原型并用药物晶体进行测试 所提出的仪器是基于激光照明和数字成像。的 第一个挑战是获得关于晶体尺寸的定量信息， 形状（基于成像的技术通常对于定量测量不可靠）。 测量）。研究人员的方法包括使用一个小的领域， 观察，以便一次观察一个单晶。传感器将用于 表明在视野中存在晶体。的数字图像 将使用新颖的线积分方法处理单晶， 获得准确的定量结果。 另一个挑战是以足够高的速率获取和处理数据， 启用过程控制。这将通过利用最新的 为机器视觉开发的成像技术。最后介绍了 该仪器将说明典型的结晶器 有限的查看权限。 拟定商业应用： 第二阶段的成功完成将导致一个非常理想的工具， 在晶体生长过程中测量晶体尺寸和形状。 这些测量将帮助用户控制和微调工艺参数。 两 已知尺寸和形状对机械和热力学性质具有强烈的影响， 晶体的性质以及晶体中液体和杂质的内含物。