FLOW CONTROL NETWORKS FOR NANOSCALE BIOFLUIDICS

纳米级生物流体的流量控制网络

• 批准号: 6310989
• 负责人: pencheng wang
• 金额: $ 18.78万
• 依托单位: CALIBRANT BIOSYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6310989
• 关键词: fluid flow; fluidity; microprocessor /microchip; miniature biomedical equipment; nanotechnology; osmotic pressure; technology /technique development

DESCRIPTION (Verbatim from the Applicant's Abstract): This proposal describes a research and development plan for novel flow control technology for the manipulation of biological fluids at the micro- and nano-scales. The technology is based on new call microfluidic field-effect control, in which a gate voltage modulates flow velocity in an electroosmotic microchannel. Unlike other methods microchannel flow manipulation, such as direct electro-osmotic flow (EOF), the field effect technique allows independent flow control in fluidic networks consisting of interconnected channels. In effect, the technology will provide discrete, integrated pumping and valving in individual microchannels with volumetric control on the order of 10^-18 liters. The technology will provide flow control in micron and sub-micron scale channels, allowing fluid manipulation at the true nano-scale. In this work, we propose to develop a discrete nanoscale flow control module, which can be integrated into traditional plastic microfluidic systems. The result will be higher of functionality, complexity, and integration in a range of miniaturized bioanalytical tools, as well as implantable or wearable noninvasive sensing systems, which require biological fluid extraction or drug mixing/delivery. PROPOSED COMMERCIAL APPLICATION: The proposed integrated flow-control technology will have a wide range of application of miniature clinical and implantable bioanalysis tools which require flow control in complex interconnected microfluidic channels. The technology is aimed at the next generation of miniaturized bioanalytical systems, with higher levels of functionality and integration than currently available systems.

描述（来自申请人摘要的逐字记录）：本提案描述了一种 新型流量控制技术的研发计划 在微米和纳米尺度上操纵生物流体。技术 是基于新的呼吁微流体场效应控制，其中栅极电压 调节电渗微通道中的流速。与其他方法不同 微通道流动操纵，例如直接电渗流（electro-osmotic flow，简称电渗流）， 场效应技术允许流体网络中的独立流动控制 由相互连接的通道组成。实际上，这项技术将提供 在单独的微通道中进行分立的、集成的泵送和阀控， 体积控制在10 -18升的数量级。这项技术将提供 微米和亚微米尺度通道中的流动控制， 真正的纳米级操控在这项工作中，我们建议开发一个 离散的纳米级流量控制模块，其可以集成到 传统的塑料微流体系统。结果会更高 功能性、复杂性和集成性， 生物分析工具，以及可植入或可穿戴的非侵入性传感 需要生物流体提取或药物混合/输送的系统。 拟定商业应用： 所提出的集成流动控制技术将在需要复杂流动控制的微型临床和植入式生物分析工具中具有广泛的应用。 相互连接的微流体通道。 该技术旨在下一代 小型化生物分析系统，具有更高水平的功能和集成度， 目前可用的系统。