SIMIAN VACCINE EVALUATION UNITS

SIMIAN 疫苗评估装置

• 批准号: 6158934
• 负责人: Phillip D Markham
• 金额: $ 169.28万
• 依托单位: ADVANCED BIOSCIENCE LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6158934
• 关键词: AIDS vaccines; Primates; active immunization; human immunodeficiency virus; simian immunodeficiency virus; technology /technique development

This contract is designed to evaluate experimental HIV vaccine strategies in non-human primates before these vaccines would proceed into clinical trials. Vaccines will be tested for safety and immunogenicity. Challenge studies using Simian Immunodeficiency Virus (SIV) or chimeric HIV/(SIV (SHIV) viruses will also be performed. Vaccine strategies investigated will include nucleic acid vaccines, recombinant proteins, whole-killed and attenuated viral vaccines as well as immunologic adjuvants and antigen delivery systems.

该合同旨在评估实验性HIV疫苗策略 在这些疫苗进行临床之前，在非人类灵长类动物中 试验。疫苗将用于安全性和免疫原性。挑战 使用Simian免疫缺陷病毒（SIV）或嵌合HIV/（SIV）的研究 （SHIV）也将进行病毒。调查了疫苗策略 将包括核酸疫苗，重组蛋白，全杀 并减弱病毒疫苗以及免疫佐剂和 抗原输送系统。