Simian Vaccine Evaluation Unit (SVEU)

猿猴疫苗评价股的主要职能如下： 1非人灵长类动物的采集和检测（主要重点是印度猕猴（Macaca mulatta）、中国猕猴或其他非人灵长类动物种属，如猪尾猕猴（Macaca nemestrina）、食蟹猴（Macaca fascicularis）、非洲绿色猴（Cercocebus atys）或狒狒。 2.非人灵长类动物的饲养和护理;动物记录的保存（提供无结核病（TB）的非人灵长类动物，这些动物也没有感染猿猴免疫缺陷病毒（SIV）、猿猴T细胞淋巴细胞病毒（STLV）和猿猴D型逆转录病毒（SRV）。为确认动物未感染这些逆转录病毒，在购买和运输至SVEU机构之前，对非人灵长类动物进行检测以筛查这些病毒。此外，检测非人灵长类动物是否存在猴疱疹B病毒抗体，以了解其血清状态。 3.协议开发 4.研究实施 5.体外实验室免疫学和病毒学试验 6.材料的储存和运输 7.将SVEU研究方案、信息和数据输入DAIDS SVEU数据库

The major functions to be carried out by the Simian Vaccine Evaluation Units (SVEUs) are as follows: 1 Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-tail macaques (Macaca nemestrina), cynomolgus monkeys (Macaca fascicularis), African green monkeys (Cercocebus atys), or baboons may be requested. 2. Housing and care of non-human primates; maintenance of animal records (Provide tuberculosis (TB)-free nonhuman primates that are also free of infection with simian immunodeficiency virus (SIV), simian T-cell lymphotrophic virus (STLV), and simian type D retrovirus (SRV). To confirm that animals are free from infection with these retroviruses, conduct testing of the nonhuman primates to screen for these viruses prior to purchase and shipment to the SVEU facility. In addition, test the nonhuman primates for the presence of antibodies to simian herpes B virus so that their serostatus is known. 3. Protocol Development 4. Conduct of Studies 5. In Vitro Laboratory Immunologic and Virologic Assays 6. Storage and shipment of materials 7. Entry of SVEU study protocols, information, and data into the DAIDS SVEU database