课题基金 / 基金详情

AMINERGIC FUNCTION IN AGING AND ALZHEIMERS DISEASE

AMINERGIC FUNCTION IN AGING AND ALZHEIMERS DISEASE
衰老和阿尔茨海默病中的胺能功能
批准号:
2683100
负责人:
PAULA C BICKFORD
金额:
$99.36万
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-03-01 至 2001-03-31

项目摘要

项目成果

PAULA C BICKFORD的其他基金

相似基金

相关文献

中文摘要
翻译
这个竞争的延续应用程序分为五个项目和
英文摘要
This competing continuation application is divided into five projects and three cores. The program project has several major scientific aims. Since its inception, we have studied changes in central noradrenergic neurotransmission during aging. This includes studies of mechanisms at the molecular and cell biological levels, as well as studies of function in terms of effects on central neuronal physiology and correlation with motor learning. We propose to characterize changes in cholinergic neurotransmission in aging as well. This includes studies of the regulation of cholinergic neurons and their targets by trophic factors, as well as studies of the relationship between functional and cognitive alterations. We have proposed studies on long term potentiation, phosphorylation, and their regulation by excitatory and inhibitory amino acids in young and aged rats. We will also study the molecular biology of age-related receptor changes. A new focus of this grant is the study of calcium channel function and its relationship to neuronal degeneration. A second new focus involves study of free radical mechanisms in aged-related dysfunctions and their reversal by spin-trap compounds. Brain cell transplants will be utilized to differentiate between intrinsic and extrinsic determinants of age-related changes. Molecular biological and functional studies of trophic factors in the neurotrophin and TGF beta families are also proposed. The experiments in this program are multidisciplinary and interactive. Biochemical and electrophysiological measurements will be made in animal models. To the greatest extent possible, appropriate tissues from the same subjects studied physiologically will be examined biochemically.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Aging and Innate immune system resilience in TBI
  • 批准号:
    10616497
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    2022
  • 负责人:
    PAULA C BICKFORD
  • 依托单位:
Aging and Innate immune system resilience in TBI
  • 批准号:
    10369760
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    2022
  • 负责人:
    PAULA C BICKFORD
  • 依托单位:
ShEEP Request for QuantStudio 12K Flex Real-Time PCR system
  • 批准号:
    9796289
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    2019
  • 负责人:
    PAULA C BICKFORD
  • 依托单位:
BLRD Research Career Scientist Award Application
  • 批准号:
    10265423
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    2018
  • 负责人:
    PAULA C BICKFORD
  • 依托单位:
海外基金