ELECTROPHYSIOLOGY OF COGNITIVE DECLINE IN AGING AND DEMENTIA

衰老和痴呆症认知衰退的电生理学

• 批准号: 2826334
• 金额: $ 23.3万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2826334
• 关键词: aging; audiometry; auditory stimulus; biomarker; brain disorder diagnosis; brain electrical activity; brain mapping; cognition disorders; conditioning; dementia; electroencephalography; evoked potentials; human old age (65+); human subject; language disorders; longitudinal human study; magnetic resonance imaging; memory disorders; postmortem; sensorimotor system; space perception; visual stimulus

The overall goal of this project is to combine longitudinal and cross sectional methodologies to identify markers of cognitive decline in normally aging and dementing individuals. In addition to the longitudinal data on changes in temporal and spatial aspects of event-related potentials (ERPs), specific experiments will assess cognitive operations that are vulnerable in the elderly and those at risk for dementia: semantic activation, elaboration at encoding on memory tasks, and motor slowing. Event-related potentials (ERPs) will be recorded from the scalp, time locked to auditory and visual stimuli. The ERP waveform is expected to vary as a function of experimental condition, age, and cognitive impairment, thus providing measures of the timing and efficiency of cognitive processing in three groups of the aged: normal, high risk for dementia, and demented. A detailed scalp topographic analysis, utilizing the Laplacian method for reference free measurements of transcranial current flow, will provide an indication of age-related change in the differential intracranial generation of these ERP components.

本项目的总体目标是将纵向和横向联合收割机相结合 部分方法，以确定认知下降的标志物， 通常是衰老和痴呆的人 除了纵向 事件相关电位的时间和空间变化数据 （ERPs），具体的实验将评估认知操作， 老年人和痴呆症高危人群中的脆弱人群：语义 激活、记忆任务编码的精细化和运动减慢。 将从头皮记录事件相关电位（ERP），时间 锁定在听觉和视觉刺激上 预期ERP波形 随着实验条件、年龄和认知能力的变化而变化。 损害，从而提供的时间和效率的措施， 三组老年人的认知过程：正常，高风险 痴呆和精神错乱 详细的头皮地形分析，利用 无参考经颅测量Laplacian方法 电流，将提供与年龄相关的变化的指示 这些ERP成分的颅内生成差异。