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GENDER DIFFERENCES IN DRUG METABOLISM--A PILOT STUDY

GENDER DIFFERENCES IN DRUG METABOLISM--A PILOT STUDY
药物代谢的性别差异——一项试点研究
批准号：
6113961
负责人：
CELESTE M LINDLEY
金额：
$1.58万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6113961
关键词：
clinical research cortisol cytochrome P450 dextromethorphan drug metabolism enzyme activity estrogens gender difference hormone regulation /control mechanism human subject liver metabolism nitrogenous heterocyclic compound progesterone

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中文摘要
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英文摘要
This pilot study will assess the effects of gender and exogenous hormones on hepatic cytochrome P450 3A4 activity in men and women. The primary objective is to compare the mean intrasubject coefficient of variation (C.V.) of the ratio of urinary 6-B-hydroxycortisol to cortisol (6-B-)H-cortisol:cortisol), determined over a four week period, among the three study groups: women not receiving exogenous hormones, women receiving Triphasil, and men. Secondary objectives include use of a second metabolic probe, dextromethorphan, and estrogen and progesterone concentrations to further assess these gender differences.
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