PHYSIOLOGY OF WATER BALANCE--RESEARCH AND EDUCATION PROJECT

水平衡生理学--研究和教育项目

• 批准号: 6263950
• 负责人: GARY L. ROBERTSON
• 金额: $ 2.05万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6263950
• 关键词: age difference; arginine vasopressin; behavioral /social science research tag; body water; clinical research; gender difference; homeostasis; human subject; physiology; racial /ethnic difference; solute; sweat; thirst; urine; vasopressins; water drinking behavior

Disorders of solute and water balance are a significant cause of morbidity and mortality in virtually all areas of medicine in every part of the world. Thus, a working knowledge of the physiology and pathophysiology of water and solute homeostasis is essential for every practicing physician. The principal elements in the control of solute and water balance in humans are well known. Some of them, such as the mechanisms that regulate the renal excretion of water and solute, have been studied extensively at the level of the cell as well as the whole body. However, much less is known about the regulation of other important variables such as intake or extrarenal output. There is even less reliable information about the way the various parts of the regulatory system interact to maintain water and solute balance in healthy people during normal activities or under the conditions in which patients are often studied and treated. Particularly lacking in this regard are reliable data concerning the scope and causes of normal variation between individuals as well as between different age, gender, ethnic or racial groups. It is clear, for example, that healthy young caucasian adults of both sexes show very large, genetically determined inter-individual differences in the osmoregulation of both thirst and secretion of the antidiuretic hormone, arginine vasopressin (1) but it is not known how these differences translate into individual variation in overall water and solute homeostasis. The best available information on normal variation in urine volume in adults (2) indicates a range from 600 to 1600 ml/24 hours but does not relate these values to gender, race, environmental conditions or variations in body size or solute load. Moreover, the validity of this normal range is highly dubious because a recent study of 12 healthy young adult volunteers in the CRC (3,4)revealed that 25% of them had urine outputs between 1800 and 3600 ml/24hours. Clearly, it is important to determine if this discrepency is due to faulty methodology in the earlier study, to hospitalization or selection bias in our own study or simply to cultural changes in eating and drinking habits in the last 50 years. Similar uncertainties pertain to the published normal values for urinary solute excretion, fluid intake and insensible water loss which must also vary markedly from person to person depending on genetic and environmental factors. Clarification of these issues is needed to provide a more rational foundation for differentiating disease from normal variation in individual patients.

溶质和水平衡紊乱是世界各地几乎所有医学领域发病率和死亡率的重要原因。因此，水和溶质稳态的生理学和病理生理学的工作知识对每个执业医生来说都是必不可少的。控制人体溶质和水平衡的主要因素是众所周知的。 其中一些机制，如调节肾脏水和溶质排泄的机制，已在细胞水平以及全身水平上进行了广泛的研究。 然而，对其他重要变量（如摄入量或肾外输出量）的调节知之甚少。 在正常活动期间或在患者经常被研究和治疗的条件下，关于调节系统的各个部分相互作用以维持健康人的水和溶质平衡的方式的可靠信息甚至更少。 这方面尤其缺乏关于个人之间以及不同年龄、性别、族裔或种族群体之间正常差异的范围和原因的可靠数据。 例如，很明显，健康的年轻白人成年人（无论男女）在口渴和抗利尿激素（精氨酸加压素）分泌的渗透调节方面表现出非常大的、遗传决定的个体间差异（1），但尚不清楚这些差异如何转化为整体水和溶质稳态的个体差异。 关于成人尿量正常变化的最佳可用信息（2）表明范围为600至1600 ml/24小时，但这些值与性别、种族、环境条件或体型或溶质负荷的变化无关。 此外，该正常范围的有效性非常可疑，因为最近对CRC中的12名健康年轻成年志愿者进行的一项研究（3，4）显示，其中25%的人的尿量在1800至3600 ml/24小时之间。 显然，重要的是要确定这种差异是由于早期研究中的错误方法，还是由于我们自己研究中的住院或选择偏见，或者仅仅是由于过去50年饮食习惯的文化变化。 类似的不确定性涉及尿溶质排泄、液体摄入和无意识失水的公布正常值，其也必须根据遗传和环境因素而在人与人之间显著变化。 需要澄清这些问题，以提供一个更合理的基础，区分疾病从正常变异的个体患者。