EFFECTS OF ISOPROTERENOL & ADENOSINE ON AUTONOMIC NERVOUS SYSTEM

异丙肾上腺素的作用

• 批准号: 6263943
• 负责人: BRUCE B LERMAN
• 金额: $ 7.95万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6263943
• 关键词: adenosine; arrhythmia; autonomic nervous system; clinical research; electrophysiology; heart rate; human subject; isoproterenol

Because arrhythmia are profoundly influenced by autonomic tone, isoproterenol and adenosine are essential tools in the cardiac electrophysiology laboratory. Frequently arrhythmia are induced only during isoproterenol washout. By studying changes in autonomic tone before, during and after infusion of isoproterenol, the investigators expect to determine if a unique phase of sympatho-vagal balance occurs during washout which could explain this window of inducibility. Because adenosine causes first antiadrenergic changes and then sympathomimetic changes, this study will delineate the time course of both and allow optimum utilization in the cardiac electrophysiology laboratory of the autonomic changes produced by adenosine. Progress report and summary of findings: Twenty patients were studied. All completed the protocol consisting of monitoring sympathetic nerve recordings, blood pressure and heart rate variability before, during and after infusion of isoproteranol and administration of adenosine.

由于心律失常受自主神经张力的深刻影响，异丙肾上腺素和腺苷是心脏电生理实验室的重要工具。 心律失常通常仅在异丙肾上腺素洗脱期间诱发。 通过研究输注异丙肾上腺素之前、期间和之后自主神经张力的变化，研究者期望确定在洗脱期间是否发生了可以解释该诱导窗口的交感神经-迷走神经平衡的独特阶段。 由于腺苷首先引起抗肾上腺素能变化，然后引起拟交感神经变化，因此本研究将描述两者的时间过程，并允许在心脏电生理实验室中最佳利用腺苷产生的自主神经变化。进展报告和结果总结：研究了20例患者。所有人都完成了方案，包括监测交感神经记录，血压和心率变异性之前，期间和之后输注异丙肾上腺素和腺苷的管理。