STEM CELL RESCUE AFTER BONE MARROW CURETTAGE FOR TREATMENT OF AMM

不可知性髓样化生（AMM）是一种由骨髓纤维化引起的进行性和无法治愈的疾病，并伴有不可避免的脾肿大和外周血白栓样病变。通过从股骨和髂骨移除纤维化/骨硬化物质并注入自体干细胞，希望通过恢复造血功能来实现持续的血液学任务。进展报告和结果总结：7例患者中，1例术后死亡（死于无关的手术事件），1例术后11个月死亡且无反应，1例术后3个月无反应。脾切除术的指征是进行性脾肿大或输血需求增加。2例脾肿大患者未见消退。在这两名患者中，一名患者随后需要脾切除术，而另一名患者的脾脏仍然肿大。在两名有明显输血需求的患者中，术前，两人现在都不需要输血，其中一名红细胞压积约为36%，另一名约为34%。

Agnogenic myeloid metaplasia (AMM) is a progressive and incurable disease caused by fibrosis of the bone marrow and accompanied by inexorable splenomegaly and leukothroblastic peripheral blood picture. By removing the fibrotic/ osteosclerotic substance from a femur and iliac crest and infusing autologous stem cells it is hoped that a sustained hematological mission owing to restored hematopoiesis will occur. Progress report and summary of findings: Of the seven patients, one died post-operatively (from an unrelated operative event), one died eleven months post-operatively and had no response, and one patient has had no response three months post-operatively. The indications for splenectomy were either progressive splenomegaly or increase in transfusion requirements. Of the two patients with significant splenomegaly, regression has not occurred. Of the two, one subsequently required splenectomy and the second still has an enlarged spleen. Of the two patients with significant transfusion requirements, pre-operatively, both are now free of the need for transfusion with one hematocrit in the order of 36% and the other approximately 34%.