POTENTIAL LOSARTAN PHENYTOIN DRUG INTERACTIONS IN VOLUNTEERS

志愿者中潜在的氯沙坦苯妥英药物相互作用

• 批准号: 6297254
• 负责人: TRACY J ALLEN
• 金额: $ 0.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6297254
• 关键词: clinical research; cortisol; cytochrome P450; dosage; drug interactions; drug metabolism; human subject; losartan; pharmacokinetics; phenytoin; urinalysis

The objective of this study will be to assess the effect, if any, of losartan on the pharmacokinetics of phenytoin and phenytoin on the pharmacokinetics of losartan. Alteration in the pharmacokinetics of losartan or phenytoin may lead to clinical effects/adverse effects requiring a dose adjustment. A secondary objective will be to establish the duration of induction once phenytoin is discontinued, by using the ration of 68-hydroxycortisol and cortisol in the urine as a marker of cytochrome P450 3A induction.

本研究的目的是评估氯沙坦对苯妥英的药代动力学和苯妥英对氯沙坦药代动力学的影响（如有）。 氯沙坦或苯妥英的药代动力学改变可能导致需要调整剂量的临床效应/不良反应。 次要目标是通过使用尿液中68-羟基皮质醇和皮质醇的比例作为细胞色素P450 3A诱导的标志物，确定苯妥英停药后的诱导持续时间。