POTENTIAL LOSARTAN PHENYTOIN DRUG INTERACTIONS IN VOLUNTEERS

本研究的目的是找出氯沙坦和苯妥英等药物的潜在相互作用。氯沙坦已被FDA批准用于治疗高血压。苯妥英也获得了FDA的批准，是治疗癫痫的最常用药物。受试者将单独服用每种药物，然后一起服用。这些药物可能在肝脏中被类似的酶代谢。如果确实发生了相互作用，这项研究将有助于确定影响的大小。

The purpose of this research study is to find out more about potential drug interactions with the medications losartan and phenytoin. Losartan has been approved by the FDA and is used to treat high blood pressure. Phenytoin has also been approved by the FDA and is most commonly used drug in the treatment of seizure disorders. Subjects will receive each of these drugs alone and then together. These drugs may be metabolized by similar enzymes in the liver. If an interaction does occur, this study will help to identify the size of the effect.