DIETARY APPROACHES TO STOP HYPERTENSION 2 (DASH2)

控制高血压的饮食方法 2 (DASH2)

• 批准号: 6297589
• 负责人: LAWRENCE APPEL
• 金额: $ 0.23万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6297589
• 关键词: biomarker; blood vessel disorder; cardiovascular disorder prevention; clinical research; diet therapy; dietary constituent; homeostasis; human subject; human therapy evaluation; hypertension; inflammation; nutrition related tag; outcomes research; salt intake; thrombomodulin; vascular endothelium

The objective of this ancillary study in DASH2 is to determine the impact of dietary patterns on markers of hemostasis, endothelial damage and inflammation as an ancillary study to DASH2, a feeding study. These factors and pathways have been associated with the occurrence of clinical cardiovascular events and represent key components in the atherosclerotic process. The main objective of DASH2 is to assess the effects of 3 salt levels in 2 dietary patterns on blood pressure in 100 adults with systolic blood pressure 120-159 mmHg and diastolic blood pressure 80 to 95 mmHg. For two weeks, participants are fed a control diet, low in fruits, vegetables, and dairy products, with fat and salt content typical of US consumption. Participants are then randomized in a parallel arm design to (1) the control diet or (2) a "combination" diet rich in fruits, vegetables, and low-fat dairy products, and reduced in saturated and total fat. Within each diet, participants receive three different sodium levels (50 mmol/d, 100 mmol/d, and 150 mmol/d), each for 30 days. Study participants will be the 100 healthy volunteers to be enrolled in DASH2 at the Johns Hopkins General Clinical Research Center. To date, we have collected blood from 35 randomized participants enrolled in the first of three feeding cohorts. Measurements for this ancillary study are taken at the last screening visit and at the conclusion of the study. No intermediate measurements are taken as sodium is not thought to play a major role in influencing the levels of the markers in question. Fibrinolytic activity is evaluated by measuring tissue plasminogen activator antigen (TPA ag) and the activity of its major inhibitor, plasminogen activator inhibitor (PAI-1 activity). Furthermore, activity coagulation is measured through Factor VII coagulant activity, homocysteine and fibrinogen measrements. Each of these factors has been independently associated with risk of major atherosclerotic events. Endothelial damage is measured by thrombomodulin (TM) and von Willebrand's factor (vWF). Finally, two markers of inflammation, C-reactive protein (CRP) and total WBC, are measured.

DASH 2中本辅助研究的目的是确定 饮食模式对止血、内皮损伤标志物的影响 和炎症作为DASH 2（喂养研究）的辅助研究。 这些 因素和途径与发生 临床心血管事件，代表了 动脉粥样硬化过程。 DASH 2的主要目标是评估 2种膳食模式中3种盐水平对100名受试者血压的影响 收缩压120-159 mmHg和舒张压120-159 mmHg的成人 压力80至95 mmHg。 在两周的时间里，参与者被喂食一种对照品， 饮食，低水果，蔬菜和乳制品，脂肪和盐 典型的美国消费。 然后，参与者被随机分配到 （1）对照饮食或（2）“组合”的平行臂设计 饮食丰富的水果，蔬菜和低脂乳制品，并减少 饱和脂肪和总脂肪含量。 在每一种饮食中，参与者都会收到 三种不同的钠水平（50 mmol/d、100 mmol/d和150 mmol/d）， 每种持续30天。 研究参与者将是100名健康志愿者， DASH 2在约翰霍普金斯综合临床研究中心。 到目前为止， 我们收集了35名随机参与者的血液， 三个喂食队列中的第一个 本辅助研究的测量值 在末次筛选访视和结束时进行 study. 没有中间测量，因为钠不被认为是 发挥重要作用，影响水平的标志物， 问题 纤溶活性通过测量组织 纤溶酶原激活物抗原（TPA ag）及其主要活性 抑制剂，纤溶酶原激活物抑制剂（派-1活性）。 此外，通过因子VII测量活性凝血 凝血活性、同型半胱氨酸和纤维蛋白原测量。 中的每 这些因素独立地与重大疾病的风险相关。 动脉粥样硬化事件 内皮损伤通过以下方式测量： 血栓调节蛋白（TM）和血管性血友病因子（vWF）。 最后，两个 炎症标志物C-反应蛋白（CRP）和总WBC， 测定了