DIETARY APPROACHES TO STOP HYPERTENSION 2 (DASH2)

控制高血压的饮食方法 2 (DASH2)

• 批准号: 6218339
• 负责人: LAWRENCE JOHN APPEL
• 金额: $ 0.23万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6218339
• 关键词: biomarker; blood vessel disorder; cardiovascular disorder prevention; clinical research; diet therapy; dietary constituent; homeostasis; human subject; human therapy evaluation; hypertension; inflammation; nutrition related tag; outcomes research; salt intake; thrombomodulin; vascular endothelium

The objective of this ancillary study in DASH2 is to determine the impact of dietary patterns on markers of hemostasis, endothelial damage and inflammation as an ancillary study to DASH2, a feeding study. These factors and pathways have been associated with the atherosclerotic process. The main objective of DASH2 is to assess the effects of 3 salt levels in 2 dietary patterns on blood pressure in 100 adults with systolic blood pressure 120-159 mmHg and diastolic blood pressure 80 to 95mmHg. For two weeks, participants are fed a control diet, low in fruits, vegetables, and diary products, with fat and salt content typical of US consumption. Participants are then randomized in a parallel arm design to (1) the control diet or (2) a 'combination' diet rich in fruits, vegetables, and low-fat dairy products, and reduced in saturated and total fat. Within each diet, participants receive three different sodium levels (50 mmol/d, 100 mmol/d, and 150 mmol/d), each for 30 days.

DASH2中这项辅助研究的目的是确定饮食模式对止血、内皮损伤和炎症标志物的影响，作为DASH2喂养研究的一项辅助研究。这些因素和途径与动脉粥样硬化过程有关。DASH2的主要目的是评估两种饮食模式中三种盐水平对100名收缩压120-159 mmHg和舒张压80 - 95mmHg的成年人血压的影响。在两周的时间里，参与者被喂食了一种控制饮食，水果、蔬菜和乳制品的含量较低，脂肪和盐的含量是典型的美国饮食。然后，参与者被随机分为两组：(1)对照饮食或(2)富含水果、蔬菜和低脂乳制品，减少饱和脂肪和总脂肪的“组合”饮食。在每种饮食中，参与者接受三种不同的钠水平（50 mmol/d， 100 mmol/d和150 mmol/d），每种水平持续30天。