Limited Competition: Continuation of Chronic Renal Insufficiency Cohort (CRC)

这份提案描述了约翰·霍普金斯大学马里兰分校未来队列的现场中心 慢性肾功能不全的研究，也称为CRIC。终末期的发病率和流行率 肾脏疾病不断增加，随之而来的是并发症，尤其是心血管疾病。 疾病。CRIC是一项纵向的观察性研究，将确定进展的风险因素 慢性肾功能不全与心血管疾病危险因素的关系 肾功能受损。参与者为3,000人(霍普金斯大学250人，马里兰州250人)，50% 糖尿病患者和50%的非糖尿病患者，估计肾小球滤过率(GFR)为30-70毫升/分钟/1.73平方米。 主要的招聘策略将是识别肌酐升高的个人， 到这个GFR范围。霍普金斯大学和马里兰州大学都已证明有能力生成这样的名单 个人。这两个医疗中心是巴尔的摩最大的医疗保健提供系统 都会区，人口160万。这两个机构的所在地应该是 减少不同人群的入学，其中许多人将是贫困的。基线数据将被收集移交 3次访问(一次简短的资格访问和2次后续访问)。结果将在年度面对面确定 通过跟踪访问和电话监测。核心衡量标准将包括问卷、GFRS 心动图和生物标本。研究调查人员有经过验证的成功记录 设计和开展大规模的协作研究。具体地说，他们成功地 有大量的参与者，取得了很高的随访率，收集了几乎所有的 这项研究中提出的主要测量方法，并通过以下方式做出了实质性的科学贡献 出版和介绍他们的调查结果。这两个机构令人印象深刻的基础设施和 (巴尔的摩大都市区的大量人口将进一步增强成功的潜力。简而言之， 霍普金斯大学马里兰分校的场上中心非常适合完成每一项主要任务： 这项至关重要的研究取得了全面的成功，并将继续与审评委的外地中心保持一致。

This proposaldescribes the Johns Hopkins-University ofMaryland field centerforthe Prospective Cohort Study of Chronic Renal Insufficiency, also termed CRIC. The incidence and prevalence of endstage kidney disease are relentlessly increasing, along with attendant co-morbidities, particularly cardiovascular disease. CRIC is a longitudinal, observational study that will determine the risk factors for progressionof chronic renal insufficiency and the risk factors for cardiovascular disease in a cohort of individuals with impaired kidney function. Participants will be 3,000 individuals (250 at Hopkins, 250 at Maryland),50% diabetic and 50% non-diabetic, with an estimated glomerular filtration rate (GFR) of 30-70 ml/min/1.73 m2. The primary recruitment strategy will be to identify individuals with an elevated creatinine thatcorresponds to this GFR range. Both Hopkins and U.Maryland have the proven capacity to generate lists of such individuals. These 2 medical centers are the largest health care delivery systems in the Baltimore metropolitan area, which is populated by 1.6 million persons. The locations of the two institutions should acilitate enrollment of a diverse cohort, many of whom will be indigent. Baseline data will be collectedover 3 visits (a brief eligibility visit and 2 subsequent visits). Outcomeswill be ascertained at an annual in-person Follow-up visit and by telephone surveillance. Core measurements will include questionnaires, GFRs chocardiograms, and biological specimens. Study investigators have a proven track record of successfully designing and conducting large-scale, collaborative research studies. Specifically, they havesuccessfully ¿ecruited large cohorts of participants, have achieved high follow-up rates, have collected virtually all of the Imajor measurements proposed in this study, and have made substantive scientific contributions through publication and presentation of their findings. The impressive infrastructure of the two institutions and the (large population of the Baltimore metropolitan area will further enhance the potential for success. Inshort, he Hopkins-U.Maryland field center is extremely well-positioned to accomplish each of the major task: equired of the CRIC field centers and to contribute to the overall success of this vitally important study.