Limited Competition: Continuation of Chronic Renal Insufficiency Cohort (CRC)

该提案描述了约翰霍普金斯大学马里兰实地研究中心的前瞻性队列 慢性肾功能不全研究，也称为CRIC。终末期癌症的发病率和患病率 肾脏疾病与伴随共病（特别是心血管疾病）一起沿着不断增加 疾病CRIC是一项纵向观察性研究，将确定疾病进展的风险因素。 慢性肾功能不全和心血管疾病的危险因素在一个队列的个人， 肾功能受损。参与者将有3,000人（霍普金斯250人，马里兰州250人），50% 糖尿病和50%非糖尿病，估计肾小球滤过率（GFR）为30-70 ml/min/1.73 m2。 主要招募策略是识别肌酐升高的个体， 到这个GFR范围。霍普金斯和马里兰州都有能力产生这样的名单， 个体这两个医疗中心是巴尔的摩最大的医疗保健提供系统 大都市区，人口160万。这两个机构的地点应 一个多样化的群体，其中许多人将是贫穷的。基线数据将在 3次访视（一次简短的合格性访视和2次后续访视）。结果将在每年一次的面对面会议上确定 随访和电话监测。核心衡量标准将包括问卷、GFRs 心电图和生物样本研究者有成功的跟踪记录， 设计和进行大规模的合作研究。具体来说，他们已经成功地 吸引了大量的参与者，实现了高随访率，几乎收集了所有的 本研究中提出的主要测量方法，并通过 发表和介绍他们的研究结果。这两个机构的基础设施令人印象深刻， （巴尔的摩大都市区的大量人口将进一步增强成功的潜力。总之， 霍普金斯大学马里兰州的现场中心非常适合完成每一项主要任务： 委员会将继续努力，确保审评委外地中心的工作得到充分的重视，并为这一至关重要的研究的全面成功作出贡献。

This proposaldescribes the Johns Hopkins-University ofMaryland field centerforthe Prospective Cohort Study of Chronic Renal Insufficiency, also termed CRIC. The incidence and prevalence of endstage kidney disease are relentlessly increasing, along with attendant co-morbidities, particularly cardiovascular disease. CRIC is a longitudinal, observational study that will determine the risk factors for progressionof chronic renal insufficiency and the risk factors for cardiovascular disease in a cohort of individuals with impaired kidney function. Participants will be 3,000 individuals (250 at Hopkins, 250 at Maryland),50% diabetic and 50% non-diabetic, with an estimated glomerular filtration rate (GFR) of 30-70 ml/min/1.73 m2. The primary recruitment strategy will be to identify individuals with an elevated creatinine thatcorresponds to this GFR range. Both Hopkins and U.Maryland have the proven capacity to generate lists of such individuals. These 2 medical centers are the largest health care delivery systems in the Baltimore metropolitan area, which is populated by 1.6 million persons. The locations of the two institutions should acilitate enrollment of a diverse cohort, many of whom will be indigent. Baseline data will be collectedover 3 visits (a brief eligibility visit and 2 subsequent visits). Outcomeswill be ascertained at an annual in-person Follow-up visit and by telephone surveillance. Core measurements will include questionnaires, GFRs chocardiograms, and biological specimens. Study investigators have a proven track record of successfully designing and conducting large-scale, collaborative research studies. Specifically, they havesuccessfully ¿ecruited large cohorts of participants, have achieved high follow-up rates, have collected virtually all of the Imajor measurements proposed in this study, and have made substantive scientific contributions through publication and presentation of their findings. The impressive infrastructure of the two institutions and the (large population of the Baltimore metropolitan area will further enhance the potential for success. Inshort, he Hopkins-U.Maryland field center is extremely well-positioned to accomplish each of the major task: equired of the CRIC field centers and to contribute to the overall success of this vitally important study.