DIETARY APPROACHES TO STOP HYPERTENSION 2 (DASH2)

控制高血压的饮食方法 2 (DASH2)

• 批准号: 6114428
• 负责人: LAWRENCE JOHN APPEL
• 金额: $ 2.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114428
• 关键词: biomarker; blood vessel disorder; cardiovascular disorder prevention; clinical research; diet therapy; dietary constituent; homeostasis; human subject; human therapy evaluation; hypertension; inflammation; nutrition related tag; outcomes research; salt intake; thrombomodulin; vascular endothelium

The objective of this ancillary study in DASH2 is to determine the impact of dietary patterns on markers of hemostasis, endothelial damage and inflammation as an ancillary study to DASH2, a feeding study. These factors and pathways have been associated with the occurrence of clinical cardiovascular events and represent key components in the atherosclerotic process. The main objective of DASH2 is to assess the effects of 3 salt levels in 2 dietary patterns on blood pressure in 100 adults with systolic blood pressure 120-159 mmHg and diastolic blood pressure 80 to 95 mmHg. For two weeks, participants are fed a control diet, low in fruits, vegetables, and dairy products, with fat and salt content typical of US consumption. Participants are then randomized in a parallel arm design to (1) the control diet or (2) a "combination" diet rich in fruits, vegetables, and low-fat dairy products, and reduced in saturated and total fat. Within each diet, participants receive three different sodium levels (50 mmol/d, 100 mmol/d, and 150 mmol/d), each for 30 days. Study participants will be the 100 healthy volunteers to be enrolled in DASH2 at the Johns Hopkins General Clinical Research Center. To date, we have collected blood from 35 randomized participants enrolled in the first of three feeding cohorts. Measurements for this ancillary study are taken at the last screening visit and at the conclusion of the study. No intermediate measurements are taken as sodium is not thought to play a major role in influencing the levels of the markers in question. Fibrinolytic activity is evaluated by measuring tissue plasminogen activator antigen (TPA ag) and the activity of its major inhibitor, plasminogen activator inhibitor (PAI-1 activity). Furthermore, activity coagulation is measured through Factor VII coagulant activity, homocysteine and fibrinogen measrements. Each of these factors has been independently associated with risk of major atherosclerotic events. Endothelial damage is measured by thrombomodulin (TM) and von Willebrand's factor (vWF). Finally, two markers of inflammation, C-reactive protein (CRP) and total WBC, are measured.

DASH2 中这项辅助研究的目的是确定 饮食模式对止血标志物、内皮损伤的影响 炎症作为 DASH2（一项喂养研究）的辅助研究。 这些 与该病的发生有关的因素和途径 临床心血管事件并代表了其中的关键组成部分 动脉粥样硬化过程。 DASH2 的主要目标是评估 2 种饮食模式中 3 种盐含量对 100 人血压的影响 收缩压 120-159 mmHg 和舒张压的成人 压力80至95毫米汞柱。 在两周的时间里，参与者被喂食对照 饮食，水果、蔬菜和乳制品含量低，脂肪和盐含量低 典型的美国消费内容。 然后参与者被随机分组 平行臂设计（1）控制饮食或（2）“组合” 饮食中富含水果、蔬菜和低脂乳制品，并减少 饱和脂肪和总脂肪。 在每种饮食中，参与者都会收到 三种不同的钠水平（50 mmol/天、100 mmol/天和 150 mmol/天）， 每个持续 30 天。 研究参与者将是 100 名健康志愿者 约翰·霍普金斯综合临床研究中心的 DASH2。 迄今为止， 我们从 35 名随机参加的参与者那里采集了血液 三个喂养组中的第一个。 本辅助研究的测量 是在最后一次筛选访问和结束时进行的 学习。 由于不考虑钠，因此没有进行中间测量 在影响标记物水平方面发挥重要作用 问题。 通过测量组织来评估纤溶活性 纤溶酶原激活剂抗原（TPA ag）及其主要活性 抑制剂，纤溶酶原激活剂抑制剂（PAI-1 活性）。 此外，凝血活性通过因子 VII 来测量 凝血活性、同型半胱氨酸和纤维蛋白原测量。 每一个 这些因素与重大风险独立相关 动脉粥样硬化事件。 内皮损伤通过以下方式测量 血栓调节蛋白 (TM) 和血管性血友病因子 (vWF)。 最后，两个 炎症标志物、C 反应蛋白 (CRP) 和总白细胞 (WBC) 测量。