INFLUENCE OF SEX HORMONES ON RISK FACTORS FOR HEART DISEASE IN WOMEN WITH NIDDM

性激素对 NIDDM 女性心脏病危险因素的影响

• 批准号: 6114589
• 负责人: MARY KORYTROWSKI
• 金额: $ 2.9万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-12-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114589
• 关键词: androgens; clinical research; coronary disorder; disease /disorder proneness /risk; female; human subject; insulin sensitivity /resistance; medical complication; noninsulin dependent diabetes mellitus; sex hormones; women's health

This study is designed to investigate the hypothesis that women with Non- Insulin Dependent Diabetes (NIDDM) have higher androgens when compared to nondiabetic women, to an enhanced risk for CAD. This study will determine whether women at risk for development of NIDDM (1st degree relative of individuals w/NIDDM, and/or with a history of gestational DM) have an increase in circulating androgens and will identify associations between measures of insulin sensitivity (SI) and cardiovascular risk.

本研究旨在探讨这一假设，即妇女与非- 胰岛素依赖型糖尿病（NIDDM）有较高的雄激素相比， 非糖尿病女性患冠心病的风险增加。本研究将确定 是否有患NIDDM风险的女性（一级亲属） 患有NIDDM和/或有妊娠期糖尿病史的个体） 增加循环雄激素，并将确定之间的关联 胰岛素敏感性（SI）和心血管风险的测量。