CORTICAL PLASTICITY AFTER STROKE--FMR MAPPING STUDY

中风后皮质可塑性--FMR映射研究

• 批准号: 6338841
• 负责人: DAVID C GOOD
• 金额: $ 16.87万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6338841
• 关键词: adult human (21+); bioimaging /biomedical imaging; brain circulation; brain interhemispheric activity; brain mapping; cerebral dominance; cerebral ischemia /hypoxia; clinical research; electrostimulus; functional ability; functional magnetic resonance imaging; hand; human subject; limb movement; motor cortex; neural inhibition; neural plasticity; oxygen tension; psychomotor function; pyramidal tracts; rehabilitation; stroke

Enhanced understanding of the natural history and mechanisms of the brain's response to stroke will facilitate the development and testing of novel approaches to the rehabilitation of stroke survivors. The goal of this project is to use advanced neuroimaging techniques to investigate the cortical changes that follow ischemic stroke, and to correlate these observations with cortical motor maps obtained with transcranial magnetic stimulation and with clinical outcome. The project will identify a variety of patterns of brain reorganization and determine which ones are common to patients with good recovery of motor function. These data, in combination with those from Dr. Pons' project, will allow identification of patterns and mechanisms of plasticity which appear to be beneficial. This may facilitate the development of novel pharmacological or behavioral interventions targeted to enhancing these mechanisms in an effort to improve the eventual functional recovery of stroke survivors. Understanding these patterns may also allow individualized selection of recovery-enhancing therapies in patients recovering from stroke, potentially decreasing both the cost of rehabilitation and the substantial burden of disability and decreased quality of life caused by this disease. We propose to use functional Magnetic Resonance (fMRI) techniques to measure cerebral activation during a variety of tasks in patients at three times during the recovery from stroke. The tasks will include simple movements of the affected hand which can easily be correlated with magnetic stimulation maps and with others' previous imaging studies of recovery from stroke, contralateral and bilateral hand movements to examine the importance of interhemispheric inhibition and mirror movements in the activation. The independent prognostic value of routinely obtained MR maps of cerebral perfusion and diffusion will also be examined. These data will also facilitate the reconciliation of the blood oxygenation- based MR data with the magnetic stimulation data, which is based upon electrical stimulation of cortical pyramidal tract cells.

加深了对自然历史和气候变化机制的理解 大脑对中风的反应将促进中风的发展和测试 中风幸存者康复的新方法。的目标是 这个项目是使用先进的神经成像技术来研究 缺血性卒中后的皮质变化及其相互关系 经颅磁图对皮质运动图的观察 刺激和临床结果。该项目将确定各种 大脑重组的模式，并确定哪些模式是共同的 运动功能恢复良好的患者。这些数据结合在一起 与庞斯博士的项目中的那些，将允许识别模式 以及看似有益的可塑性机制。今年5月 促进新的药理学或行为学的发展 旨在加强这些机制的干预措施，以努力 改善卒中幸存者的最终功能恢复。 了解这些模式还可能允许个性化地选择 中风康复期患者的促进康复治疗， 潜在地降低了修复成本和实质性的 这种疾病造成的残疾负担和生活质量下降。 我们建议使用功能磁共振(FMRI)技术来 在3小时内测量患者在不同任务中的大脑活动 中风恢复期的次数。这些任务将包括简单 受影响的手的运动，很容易与 磁刺激图和其他人以前的成像研究 中风、对侧和双侧手部运动的恢复 检查大脑半球间抑制和镜像运动的重要性 在激活过程中。常规方法获得的独立预后价值 还将检查脑血流灌注和弥散的磁共振图像。这些 数据还将有助于调节血液氧合- 基于磁刺激数据的MR数据，该磁刺激数据基于 电刺激皮质锥体束细胞。