CLINICAL EXPERIENCE AND USE OF VIGABATRIN IN PATIENTS WITH INFANTILE SPASMS

婴儿痉挛是发生在婴儿身上的一种严重的癫痫发作。患有婴儿痉挛的儿童的前景很差：大多数是发育障碍，大多数仍然患有严重的癫痫。促肾上腺皮质激素是婴儿痉挛最常用的治疗方法，至少有70%的患者暂时成功。传统的抗惊厥药只是偶尔有效。Vigabatrin，一种新的抗惊厥药，正在评估治疗婴儿痉挛的安全性和有效性。

Infantile spasms are a severe type of seizures which occur in infants. The outlook for a child with infantile spasms is poor: most are developmentally disabled, and a majority continue to have severe epilepsy. ACTH is the most commonly used treatment for infantile spasms and is successful at least temporarily in about 70% However, adverse effects are significant. Conventional anticonvulsants are only occassionally effective. Vigabatrin, a new anticonvulsant, is being evaluated for safety and efficacy in treating infantile spasms.