SPUTUM CYTOLOGY & URINARY BOMBESIN LIKE PEPTIDE LEVELS

痰细胞学检查

• 批准号: 6304207
• 负责人: Cecile S Rose
• 金额: $ 3.22万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6304207
• 关键词: asbestos; biomarker; bombesin like peptide; cancer risk; cellular oncology; clinical research; cytodiagnosis; human subject; lung neoplasms; occupational hazard; sputum; urinalysis

The major goal of this proposal is to investigate biomarkers of lung cancer risk in a population with occupational exposure to asbestos, a known pulmonary carcinogen. Sputum cytology and urinary bombesin-like peptide (BLP) levels are the biomarker outcome variables. We have completed data collection on 220 study participants meeting eligibility criteria of age >40 years and at least 15 years of asbestos exposure. We have found high prevalence rates of radiographic asbestos-related disease (16% asbestosis and 31% pleural abnormalities); high rates of airflow limitation (51% with FEV1 <71% previded); and high rates of sputum cellular atypica (28% moderate atypia, 49% mild atypia, 4% squamous metaplasia, 19% normal and 10% unsatisfactory specimens). These data demonstrate our ability to recruit individuals at high risk for lung cancer, show that sputum cytology abnormalities are frequent in asbestos-exposed construction trades workers and lay the foundation for a chemoprevention trial.

这项提案的主要目标是调查职业暴露于石棉（一种已知的肺致癌物）的人群中肺癌风险的生物标志物。 痰液细胞学和尿铃蟾肽样肽（BLP）水平是生物标志物结果变量。 我们已经完成了对220名符合资格标准的年龄>40岁和至少15年石棉暴露的研究参与者的数据收集。 我们发现放射学石棉相关疾病的患病率很高（16%石棉沉滞症和31%胸膜异常）;气流限制率很高（51%，FEV 1 <71%）;痰细胞非典型性率很高（28%中度非典型性，49%轻度非典型性，4%鳞状化生，19%正常，10%不满意标本）。 这些数据表明我们有能力招募肺癌高危人群，表明痰细胞学异常在石棉暴露的建筑行业工人中很常见，并为化学预防试验奠定了基础。