EFFECTS OF ETHNICITY ON CYTOCHROME P450 IN HLTHY INDIVS USING MIDAZOLAM

民族对使用咪达唑仑的 HLTHY 个体细胞色素 P450 的影响

• 批准号: 6304497
• 负责人: SHIRLEY TSUNODA
• 金额: $ 4.27万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6304497
• 关键词: African American; caucasian American; clearance rate; clinical research; clinical trial phase I; combination chemotherapy; cytochrome P450; human subject; intravenous administration; ketoconazole; midazolam; pharmacokinetics; preoperative state; racial /ethnic difference

There is little available data on the effects of ethnicity on drug disposition. Understanding the activity of the cytochrome P450 3A4 enzyme (CYP3A4) is important to the metabolism of a wide variety of xenobiotics. Midazolam has recently been studied as an attractive in vivo probe for CYP3A4. The pharmacokinetics of oral and intravenous midazolam will be studied in twenty-four healthy African-American and Caucasian individuals.

关于种族对药物处置的影响，现有数据很少。了解细胞色素P450 3A4酶（CYP3A4）的活性对多种异生物质的代谢非常重要。最近研究了咪达唑仑作为CYP 3A4的有吸引力的体内探针。 将在24名健康的非裔美国人和白人个体中研究口服和静脉注射咪达唑仑的药代动力学。