红酒对健康个体细胞色素 P450 3A4 活性的影响-猫眼课题宝

红酒对健康个体细胞色素 P450 3A4 活性的影响

批准号：

6304507

负责人：

SHIRLEY TSUNODA

金额：

$4.27万

依托单位：

TUFTS MEDICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

1999

资助国家：

美国

项目状态：

已结题

起止时间：

1999-12-01 至 2001-02-28

来源：

https://reporter.nih.gov/project-details/6304507

关键词：

alcoholic beverages biomarker blood chemistry clinical research clinical trial phase I cyclosporines cytochrome P450 drug metabolism drug screening /evaluation enzyme activity enzyme inhibitors fluorescence polarization human subject immunologic assay /test oxygenases pharmacokinetics

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英文摘要

Commonly ingested compounds such as grapefruit juice and red wine may have effects on the therapeutic efficacy of drugs metabolized by the cytochrome P450 3A4 (CYP3A4) enzyme. Our previous in vitro work suggests that red wine may inhibit CYP3A4 to a similar degree as found with grapefruit juice. Our current investigation purposes to determine whether inhibition of CYP3A4 by red wine can result in clinically significant elevations in drug levels. This study will investigate twelve healthy volunteers in a two-way cross-over study. A single 8 mg/kg oral dose of cyclosporine (a marker for CYP3A4 activity) will be given with water and red wine on separate occasions. Whole blood levels will be drawn and analyzed by a specific fluorescence polarization immunoassay, and the pharmacokinetics of cyclosporine will be compared.

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