CLINICAL EXPERIMENT OF HELICOBACTER PYLORI TRANSMISSION

幽门螺杆菌是一种已知会导致消化性溃疡和胃癌的细菌。尽管幽门螺杆菌通常会感染人类，但它的传播方式仍不清楚。如果不知道感染是如何传播的，就很难预防感染的发生。在这项研究中，我们试图确定人类--幽门螺杆菌的主要宿主--是如何将有机体排放到环境中的。由于幽门螺杆菌生活在胃中，我们推测它是通过口腔或粪便排泄出来的。在这项研究中，我们从健康的年轻志愿者的唾液、呕吐物、呕吐期间的空气和粪便(腹泻和正常)中寻找幽门螺杆菌。为了做到这一点，我们让患者进入综合临床研究中心，并使用常见的非处方药诱导短期呕吐和腹泻。我们还评估了胃的分泌酸能力是否会影响幽门螺杆菌是否从粪便中排出。我们希望通过了解幽门螺杆菌的传播，我们将能够更好地预防感染及其相关疾病在未来。

Helicobacter pylori is a bacterium known to cause peptic ulcer disease and stomach cancer. Although H. pylori commonly infects humans, its mode of transmission remains unknown. Without knowing how infection is transmitted, it is difficult to prevent infection from occurring. In this study, we are seeking to determine how humans-the primary host for H. pylori-shed the organism into the environment. Because H. pylori lives in the stomach, we presume it is excreted through the mouth or in stools. In this study, we intensively look for H. pylori in saliva, vomit, air during vomiting and in stools (both diarrheal and normal) from healthy young volunteers. To do this, we admit patients to the General Clinical Research Center and induce short periods of vomiting and diarrhea using common over-the-counter medications. We also evaluate whether the ability of the stomach to secrete acid affects whether H. pylori is excreted in stools. It is our hope that by understanding H. pylori transmission, we will better be able to prevent infection and its associated diseases in the future.