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TAMOXIFEN AND 9 CIS RETINOIC ACID IN ADVANCED BREAST CANCER

TAMOXIFEN AND 9 CIS RETINOIC ACID IN ADVANCED BREAST CANCER
他莫昔芬和 9 顺式维甲酸治疗晚期乳腺癌
批准号：
6305874
负责人：
CAROLYN WASSERHEIT
金额：
$2.1万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6305874
关键词：
breast neoplasms clinical research clinical trial phase I combination chemotherapy drug screening /evaluation female human subject human therapy evaluation neoplasm /cancer chemotherapy pharmacokinetics retinoate tamoxifen

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中文摘要
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英文摘要
This Phase I trial will attempt to determine the maximally tolerated dose and pharmacokinetics of a combination of standard dose tamoxifen with 9-cis retinoic acid. Dose-limiting toxicity, response rate, duration of response, and survival will be determined. Levels of the various subtypes of retinoic acid receptors, retinoid X receptor, and retinoid orphan receptor mRNA and protein in tissue derived from the patient's primary and metastatic tumors will be characterized. The Core Laboratory has produced, purified, and titered an adenovirus vector expressing the retinoic acid receptor for preclinical studies relevant to breast cancer. The Core Laboratory was utilized for use of laminar flow hoods and recombinant DNA Techniques.
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DOXIL & TAXOTERE IN PATIENTS W/ ADVANCED MALIGNANCIES
TAMOXIFEN AND 9 CIS RETINOIC ACID IN ADVANCED BREAST CANCER
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