ANTIPHOSPHOLIPID SYNDROME REGISTRY (APSCORE)

这份合同是关于抗磷脂综合征(APS)的注册和存储库，它将 使研究人员能够识别基本的免疫和遗传异常， 血栓形成、胎儿丢失和其他临床疾病的病理生理机制 APS的表现。此外，书记官处将是旨在实现以下目标的项目的主要资源 改进诊断方法，评估更有效、更安全的治疗方法 和预防措施。注册中心将收集和更新临床、人口学和实验室数据 对APS患者、无症状的抗磷脂抗体患者和某些 具有血清学和/或临床特征，属于扩大的APS概念的个人。 新的分类标准的可获得性将有助于解决相关问题 疾病的异质性和临床研究项目之间更好的比较。注册是一个多中心、多专业、协作项目，涉及一组领先的AP 研究人员(风湿科医生、血液科医生、神经科医生和产科医生) 医疗中心。

This contract is for a Registry and Repository for Antiphospholipid Syndrome (APS) that will enable investigators to identify basic immunological and genetic abnormalities, pathophysiological mechanisms contributing to thrombosis, fetal loss, and other clinical manifestations of APS. In addition, the Registry will be a key resource for projects aimed at improving methods of diagnosis and evaluating more effective and safer methods of treatment and prophylaxis. The registry will collect and update clinical, demographic, and laboratory data on patients with APS, asymptomatic patients with antiphospholipid antibodies, and certain individuals with serological and/or clinical features that fall within an expanded concept of APS. The availability of new classification criteria will allow resolution of the problems associated with disease heterogeneity and better comparisons among clinical research projects. The registry is a multi-center, multi-speciality, collaborative project involving a group of leading APS investigators (rheumatologists, hematologists, neurologists and obstetricians) at 8 academic medical centers.