High Permeability, Long-Wear Contact Lens Materials

描述(摘自申请者的摘要)：这个项目的目标是开发一种具有更高性能的隐形眼镜材料 比其他市售硬质透气材料的透氧性 镜头(RGPS)。高透氧率透镜的成功开发将 在不损害眼睛健康的情况下，允许更长的佩戴时间表。 在第一阶段，紧凑型膜系统公司展示了CMS共聚物 显示了隐形眼镜材料所需的特性。这些材料有 卓越的光学性能和极高的气体渗透率 超过当前RGP材料的几倍，并且不会限制 可供角膜使用的氧气。一种材料的加工性和成型性 材料与其他RGP材料相比，排名非常有利。这个 共聚物还能抵抗蛋白质和脂肪沉积。另外， 研究表明，表面可以用各种技术进行处理。 改善润湿性是另一个重要特点。 第二阶段的工作将包括： 表面改性的最优化 精炼成型和制造工艺 透镜设计的发展 临床前和“原则证明”临床试验 商业化计划的制定 这些任务的完成将产生一种安全、有竞争力的隐形眼镜材料 适用于日常、永久或长时间佩戴。 建议的商业应用： 不可用。

DESCRIPTION (From the Applicant's Abstract): The objective of this program is to develop a contact lens material with higher oxygen permeability than other commercially available rigid gas permeable lenses (RGPs). Successful development of a high oxygen permeability lens will allow for much longer wear schedules without compromising ocular health. During Phase I, Compact membrane Systems, Inc. demonstrated that CMS copolymers showed characteristics desired of a contact lens material. These materials have exceptional optical properties, and extremely high gas permeabilities that exceed those of current RGP materials severalfold, and would not limit the oxygen available to the cornea. The machineability and moldability of one material was compared with other RGP materials, and ranked very favorably. The copolymer was also resistant to protein and lipid deposition. Additionally, studies showed that the surface could be treated with a variety of techniques to improve wettability, another important feature. The Phase II effort will include: Optimization of surface modifications Refining of molding and manufacturing processes Development of lens design Preclinical and "proof of principle" clinical trials Development of a commericialization plan Completion of these tasks will yield a safe, competitive contact lens material for daily, permamnent, or extended wear. PROPOSED COMMERCIAL APPLICATION: Not Available.