High Permeability, Long-Wear Contact Lens Materials

高渗透性、长效隐形眼镜材料

• 批准号: 6404055
• 负责人: NINA M Lamba-Kohli
• 金额: $ 37.51万
• 依托单位: COMPACT MEMBRANE SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6404055
• 关键词: biomaterial development /preparation; biomaterial evaluation; chemical synthesis; contact lens; fluorocarbon polymers; hypoxia; membrane permeability; oxygen transport

DESCRIPTION (From the Applicant's Abstract): The objective of this program is to develop a contact lens material with higher oxygen permeability than other commercially available rigid gas permeable lenses (RGPs). Successful development of a high oxygen permeability lens will allow for much longer wear schedules without compromising ocular health. During Phase I, Compact membrane Systems, Inc. demonstrated that CMS copolymers showed characteristics desired of a contact lens material. These materials have exceptional optical properties, and extremely high gas permeabilities that exceed those of current RGP materials severalfold, and would not limit the oxygen available to the cornea. The machineability and moldability of one material was compared with other RGP materials, and ranked very favorably. The copolymer was also resistant to protein and lipid deposition. Additionally, studies showed that the surface could be treated with a variety of techniques to improve wettability, another important feature. The Phase II effort will include: Optimization of surface modifications Refining of molding and manufacturing processes Development of lens design Preclinical and "proof of principle" clinical trials Development of a commericialization plan Completion of these tasks will yield a safe, competitive contact lens material for daily, permamnent, or extended wear. PROPOSED COMMERCIAL APPLICATION: Not Available.

描述（来自申请人的摘要）： 本计划的目标是开发一种具有更高折射率的接触透镜材料。 氧渗透性比其他市售的刚性气体可渗透的 晶状体（RGP）。高透氧性透镜的成功开发将 允许更长的佩戴时间表，而不会损害眼睛健康。 在第一阶段，紧凑型膜系统公司。表明CMS共聚物 显示出接触透镜材料所需的特性。这些材料具有 优异的光学性能和极高的气体渗透性， 超过目前的RGP材料的几倍，不会限制 角膜可获得的氧气。一个人的可加工性和可成型性 材料与其他RGP材料相比，排名非常有利。的 共聚物还抵抗蛋白质和脂质沉积。此外，本发明的目的是， 研究表明，表面可以用各种技术处理， 以改善润湿性，这是另一个重要特征。 第二阶段的工作将包括： 表面改性的优化 优化成型和制造工艺 透镜设计的发展 临床前和“原理证明”临床试验 制定专业化计划 完成这些任务将产生一种安全、有竞争力的接触透镜材料 用于日常、永久或长期佩戴。 拟定商业应用： 不可用.