Biocidal Surfaces for Medical Hardware

医疗硬件的杀菌表面

• 批准号: 7328143
• 负责人: NINA M Lamba-Kohli
• 金额: $ 10万
• 依托单位: CCL BIOMEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-08 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7328143
• 关键词: Acute; Antibiotic Resistance; Bacteria; Biocide; Caring; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chemicals; Clinical; Clinical Research; Complement; Computers; Condition; Construction Materials; Coupling; Disruption; Economics; Engineering; Environment; Equipment; Family; Financial cost; Funding; Glass; Hand; Handwashing; Health Care Costs; Health Personnel; Health Professional; Healthcare Industry; Hospitals; Hour; Human Resources; Hygiene; Immobilization; Infection; Infection Control; Laboratories; Laboratory Study; Legal patent; Length of Stay; Longevity; Manpower Need; Measures; Medical; Membrane; Methods; Microbe; Modeling; Modification; Molds; Nosocomial Infections; Numbers; Outcome; Pain; Patients; Patients' Rooms; Performance; Phase; Play; Polymers; Polyurethanes; Privacy; Range; Rate; Role; Running; Severities; Silicone Elastomers; Skilled Nursing Facilities; Solid; Solutions; Stainless Steel; Surface; Technology; Testing; United States; Use Effectiveness; Virus; Week; Workload; antimicrobial; antimicrobial drug; bacterial resistance; clinically relevant; commercialization; cost; improved; killings; microbial; microorganism; migration; pathogen; pathogenic bacteria; prevent; programs; scale up; transmission process

DESCRIPTION (provided by applicant): Each year, 5-10% of patients admitted to acute care hospitals in the United States (1.75- 3.5 million people) acquire an infection while in hospital. Consequences of hospital-acquired (nosocomial) infections include prolonged hospital stays, increased pain and discomfort for the patient, and even death. The number of deaths per year caused by nosocomial infections may exceed 100,000. The inflated costs of healthcare run into billions of dollars annually. The number and severity of infections is increasing, with antibiotic resistant strains causing a greater proportion of those infections. It is widely accepted that lapses in hygiene can contribute to infections, and that inanimate objects can play a role in the transmission of microbes. Recent laboratory and clinical studies have shown that bacteria can survive for weeks and even months on items such as privacy curtains, computer keyboards, and keypads on medical equipment. Technologies that prevent the proliferation and transmission of microbes without an increase in manpower are needed to supplement other infection control practices to improve patient outcomes. CCL Biomedical has identified a unique biocidal family that kills bacteria and other microbes on contact. The biocide is can be chemically attached to articles under mild conditions. Chemical attachment to a surface reduces migration of the biocide into the environment. Treated surfaces will kill any microbes that settle on the surface. Furthermore, the biocide is not consumed by the microorganism, meaning that the treatment can provide continuous protection. During the Phase I program, we will treat a number of model surfaces with our biocidal compounds, and test them for antimicrobial effectiveness using clinically relevant bacteria in laboratory studies. Representative materials include glass, stainless steel, polyurethane, and silicone rubber. During Phase II, microbiological studies will be expanded to include viruses and molds. Treated surfaces will be tested for durability, migration, and longevity. Toxicological testing will also be performed. By developing biocidal surface treatments, we aim to improve the outcome for patients, without adding to the workload of healthcare workers and janitorial staff. Project Summary Each year, 5-10% of patients (1.75-3.5 million people) admitted to acute care hospitals in the United States acquire an infection while in hospital. The total cost to the healthcare industry runs in the billions of dollars, and infections result in increased pain and discomfort for the patient, and approximately 100,000 deaths per year. Although the most important aspect of infection control is hand-washing, inanimate items can play a role in the transmission of infection. We propose to develop a solution that can be applied to medical hardware and furnishings to reduce the viability of microbes that may be transferred between such items and the hands. This will reduce the number of hospital-acquired infections.

描述（由申请人提供）：每年，美国急诊医院收治的5-10%的患者（175 - 350万人）在住院期间感染。医院获得性（院内）感染的后果包括延长住院时间，增加患者的疼痛和不适，甚至死亡。每年因医院感染造成的死亡人数可能超过10万人。每年医疗保健成本上涨高达数十亿美元。感染的数量和严重程度正在增加，其中抗生素耐药菌株导致更大比例的感染。 人们普遍认为，卫生方面的失误会导致感染，而无生命的物体也会在微生物的传播中发挥作用。最近的实验室和临床研究表明，细菌可以在隐私窗帘，电脑键盘和医疗设备上的广告等物品上存活数周甚至数月。需要在不增加人力的情况下防止微生物增殖和传播的技术来补充其他感染控制实践，以改善患者的治疗效果。CCL Biomedical已经确定了一种独特的生物杀灭剂家族，可以杀死接触的细菌和其他微生物。杀生物剂可以在温和条件下化学附着到物品上。与表面的化学附着减少了杀生物剂向环境中的迁移。经过处理的表面会杀死任何附着在表面上的微生物。此外，杀生物剂不被微生物消耗，这意味着处理可以提供连续的保护。 在第一阶段计划中，我们将用我们的杀菌化合物处理一些模型表面，并在实验室研究中使用临床相关细菌测试它们的抗菌效果。代表性材料包括玻璃、不锈钢、聚氨酯和硅橡胶。在第II阶段，微生物研究将扩大到包括病毒和霉菌。将对经处理的表面进行耐久性、迁移和寿命测试。还将进行毒理学试验。通过开发杀菌表面处理，我们的目标是改善患者的治疗效果，而不会增加医护人员和清洁人员的工作量。在美国，每年有5-10%的急诊患者（175 - 350万人）在住院期间感染。医疗保健行业的总成本高达数十亿美元，感染导致患者疼痛和不适增加，每年约有10万人死亡。虽然感染控制最重要的方面是洗手，但无生命的物品也会在感染传播中发挥作用。我们建议开发一种可应用于医疗硬件和家具的解决方案，以减少可能在这些物品和手之间转移的微生物的活力。这将减少医院获得性感染的数量。