COMPTON IMAGING PROBE FOR THE PROSTATE

这项R21/R33研究的长期目标是基于康普顿散射相机的想法开发一种新的用于前列腺的核医学成像探针。当探头靠近感兴趣器官时，可以同时实现高空间分辨率和高计数效率，并且与传统的康普顿相机不同，探头不受多普勒展宽效应的显著影响。由于它靠近物体，康普顿探头可以很小，因此与用于身体成像的康普顿相机相比相对便宜。在R21阶段，将研究该探头在前列腺成像方面优于传统的PET和SPECT仪器的可能性。用于前列腺成像的探头和常规系统的性能将使用包括均匀Cramer-Rao界限、理想观察者和信道化霍特林观察者在内的多个测量来量化。将使用现有的硅探测器和C-Sprint康普顿相机构建一个原型探测器。使用探测器的体模测量的统计数据将被用来证实对性能测量的预测。FF调查表明，该探头提供了明显更好的前列腺图像，康普顿探头的全面开发，初步的患者成像研究将在R33阶段进行。R33的令人鼓舞的结果将刺激商业化。

The long-term objective of this R21/R33 investigation is to develop a new nuclear medicine imaging probe for the prostate based on the idea of the Compton scatter camera. When placed close to the organ of interest the probe can achieve high spatial resolution and high counting efficiency simultaneously, and unlike the conventional Compton camera, probes are not significantly influenced by the effects of Doppler broadening. Because of its proximity to the object, the Compton probe Can be small and therefore relatively inexpensive in comparison to a Compton camera for body imaging. In the R21 phase, the possibility for this probe to outperform conventional PET and SPECT instrumentation for prostate imaging will be examined. Performance of the probe and conventional systems for imaging the prostate will be quantified using several measures including the uniform Cramer-Rao bound, the ideal observer, and the channelized Hotelling observer. A prototype probe will be constructed using existing silicon detectors and the C-SPRINT Compton camera. Statistics from phantom measurements using the probe will be used to corroborate predictions of the performance measures. ff the investigation indicates that the probe provides significantly better images of the prostate, full-scale development of the Compton probe and preliminary patient imaging studies will be conducted in the R33 phase. Encouraging results in R33 will stimulate commercialization.