Radionuclides: Radiation Detection and Quantification

描述（由申请人提供）：研究用于核医学和分子成像的新型成像系统仍然是本项目的长期目标。在过去的几年里，研究集中在康普顿散射相机和它们的潜力，提供显着的改善传统的吸收准直单光子成像。到目前为止的结果表明，康普顿相机将提供上级性能在能量> 240千电子伏或当操作在康普顿探头安排。然而，仍然需要工作来创建具有大约1 keV FWHM的能量分辨率的散射检测器的大阵列。在本项目期间，研究方向将略有变化，重点是开发超高分辨率（VHP）PET概念，这是康普顿相机研究的结果，并在上次更新中报告。最近，0.8mm的FWHM空间分辨率已被证明使用这种技术和本调查的目的是评估一个实用的设备相对于目前的小动物PET技术的性能，并开发必要的技术，使小动物的分子成像的分辨率仅限于正电子范围的效率接近10%。调查的主要具体目的是：1。评价VHR PET概念优于更传统设计的PET仪器的潜力。这将通过使用基于Cramer-Rao界限的统计性能评价方法来实现。2.建造一个PET试验台，在此基础上测试新的VHR PET技术。3.进一步发展高分辨率固态探测器和读出技术，以确定这一概念的可行性。这项工作将与密歇根大学、俄亥俄州州立大学、欧洲核研究组织（日内瓦）、瓦伦西亚大学（西班牙）和卢布尔雅那大学（斯洛文尼亚）合作完成。这项研究的结果不仅将是一个令人信服的VHR PET概念的演示，但也将提供必要的技术，以推进VHR PET和康普顿相机。

DESCRIPTION (provided by applicant): The investigation of novel imaging systems for nuclear medicine and molecular imaging continues to be the long-term objective of this project. For the previous several years investigations have focused on Compton scatter cameras and their potential for providing significant improvements over conventional absorbing collimation for single photon imaging. Results so far indicate that Compton cameras will provide superior performance at energies >240keV or when operated in a Compton probe arrangement. Nevertheless, work is still required to create large arrays of scattering detectors having energy resolution approximately 1keV FWHM. In the this project period, investigations will change directions slightly and focus on developing the very high resolution (VHP) PET concept, which was conceived as result of the Compton camera investigations and reported in the last renewal. Recently, 0.8mm FWHM spatial resolution has been demonstrated using this technique and the goal of this investigation is to evaluate performance of a practical device relative to present small animal PET technologies and to develop technologies necessary to allow molecular imaging of small animals with resolution limited only by the positron range at efficiencies approaching 10%. The major Specific Aims of the investigation are: 1. Evaluate the potential for the VHR PET concept to outperform PET instruments of more conventional design. This will be accomplished by using statistical performance evaluation methods based on the Cramer-Rao bound. 2. Construct a PET test bench upon which the new VHR PET technologies will be tested. 3. Further develop the high-resolution solid-state detector and readout technologies necessary to establish feasibility of the concept. Work will be done in a collaboration that includes the University of Michigan, Ohio State University, CERN (Geneva), the University of Valencia (Spain), and the University of Ljubljana (Slovenia). Results of this investigation will not only be a compelling demonstration of the VHR PET concept but will also provide technologies necessary to advance both VHR PET and Compton cameras.