Radionuclides: Radiation Detection and Quantification

描述（由申请人提供）：研究核医学和分子成像的新型成像系统仍然是本项目的长期目标。在过去的几年里，研究主要集中在康普顿散射相机和他们的潜力，提供了显著改进传统的吸收准直的单光子成像。到目前为止的结果表明，康普顿相机将提供卓越的性能在能量bb0 240keV或在康普顿探针安排下操作。尽管如此，仍然需要制造能量分辨率约为1keV FWHM的大型散射探测器阵列。在这个项目期间，研究将稍微改变方向，重点发展非常高分辨率（VHP） PET概念，这是康普顿相机研究的结果，并在上次更新中报告。最近，0.8mm FWHM空间分辨率已经使用该技术进行了演示，本研究的目标是评估相对于现有小动物PET技术的实用设备的性能，并开发必要的技术，使小动物分子成像的分辨率仅受正电子范围的限制，效率接近10%。调查的主要具体目的是：1。评估VHR PET概念的潜力，使其优于传统设计的PET仪器。这将通过使用基于Cramer-Rao界的统计性能评估方法来完成。2. 建立一个PET测试台，在上面测试新的VHR PET技术。3. 进一步发展高分辨率固态探测器和读出技术，以建立该概念的可行性。工作将在密歇根大学、俄亥俄州立大学、欧洲核子研究中心（日内瓦）、瓦伦西亚大学（西班牙）和卢布尔雅那大学（斯洛文尼亚）的合作下完成。这项调查的结果不仅将是VHR PET概念的一个令人信服的演示，而且还将提供必要的技术来推进VHR PET和康普顿相机。

DESCRIPTION (provided by applicant): The investigation of novel imaging systems for nuclear medicine and molecular imaging continues to be the long-term objective of this project. For the previous several years investigations have focused on Compton scatter cameras and their potential for providing significant improvements over conventional absorbing collimation for single photon imaging. Results so far indicate that Compton cameras will provide superior performance at energies >240keV or when operated in a Compton probe arrangement. Nevertheless, work is still required to create large arrays of scattering detectors having energy resolution approximately 1keV FWHM. In the this project period, investigations will change directions slightly and focus on developing the very high resolution (VHP) PET concept, which was conceived as result of the Compton camera investigations and reported in the last renewal. Recently, 0.8mm FWHM spatial resolution has been demonstrated using this technique and the goal of this investigation is to evaluate performance of a practical device relative to present small animal PET technologies and to develop technologies necessary to allow molecular imaging of small animals with resolution limited only by the positron range at efficiencies approaching 10%. The major Specific Aims of the investigation are: 1. Evaluate the potential for the VHR PET concept to outperform PET instruments of more conventional design. This will be accomplished by using statistical performance evaluation methods based on the Cramer-Rao bound. 2. Construct a PET test bench upon which the new VHR PET technologies will be tested. 3. Further develop the high-resolution solid-state detector and readout technologies necessary to establish feasibility of the concept. Work will be done in a collaboration that includes the University of Michigan, Ohio State University, CERN (Geneva), the University of Valencia (Spain), and the University of Ljubljana (Slovenia). Results of this investigation will not only be a compelling demonstration of the VHR PET concept but will also provide technologies necessary to advance both VHR PET and Compton cameras.