ProSPECTuS: Preclinical Trials

招股说明书：临床前试验

• 批准号: ST/K002988/1
• 负责人: Andrew Boston
• 金额: $ 16.18万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FK002988%2F1
• 关键词: ProSPECTuS; Preclinical; Trials

Single Photon Emission Computed Tomography (SPECT) is a widely used imaging modality in medicine which uses radio-pharmaceuticals labelled with gamma emitting radioisotopes. Existing SPECT systems have a limiting position resolution of about 10 mm for body imaging and 7 mm for the head. The proposed system will offer an image resolution of 2-3 mm with a sensitivity a factor of ~100 larger than existing systems, while simultaneously enabling SPECT/MRI multimodality imaging. The ProSPECTus imager will open existing markets worth in excess of £300M pa to UK companies, covering medical, pharmaceutical, homeland security, science and defence. The consortium brings an internationally leading reputation and many years experience with semiconductor radiation detectors, electronics and software design. Key clinical input and trials are provided through Clinicians at the Clatterbridge Centre for Oncology , the University of Liverpool Magnetic Resonance Imaging Analysis Research Centre [MARIARC] and the Interventional Radiology and Medical Imaging Group at the Royal Liverpool University NHS Trust.

单光子发射计算机断层扫描（SPECT）是医学中广泛使用的成像模式，其使用用γ发射放射性同位素标记的放射性药物。现有的SPECT系统对于身体成像具有约10 mm的极限位置分辨率，对于头部具有7 mm的极限位置分辨率。所提出的系统将提供2-3 mm的图像分辨率，灵敏度比现有系统高约100倍，同时能够实现SPECT/MRI多模态成像。ProSPECTus成像仪将为英国公司打开现有市场，价值超过3亿英镑，涵盖医疗，制药，国土安全，科学和国防。该联盟在半导体辐射探测器、电子和软件设计方面拥有国际领先的声誉和多年的经验。通过Clatterbridge肿瘤中心、利物浦大学磁共振成像分析研究中心[MARIARC]和皇家利物浦大学NHS信托基金的介入放射学和医学成像组的临床医生提供关键临床输入和试验。

项目成果

Semiconductor detectors for Compton imaging in nuclear medicine

用于核医学康普顿成像的半导体探测器

• DOI: 10.1088/1748-0221/7/01/c01004
• 发表时间: 2012
• 期刊: Journal of Instrumentation
• 影响因子: 1.3
• 作者: Harkness L

A Compton camera application for the GAMOS GEANT4-based framework

用于基于 GAMOS GEANT4 框架的康普顿相机应用程序

• DOI: 10.1016/j.nima.2011.12.058
• 发表时间: 2012
• 期刊: Accelerators, Spectrometers, Detectors and Associated Equipment
• 作者: Harkness L

Characterisation of a Si(Li) orthogonal-strip detector

Si(Li) 正交带状探测器的表征

• DOI: 10.1016/j.nima.2013.05.143
• 发表时间: 2013
• 期刊: Accelerators, Spectrometers, Detectors and Associated Equipment
• 作者: Harkness L