Recruiting multiethnic populations to preclinical Alzheimers disease trials-Diversity Supplement

家长研究项目摘要 阿尔茨海默病(AD)和相关痴呆症(ADRD)对代表不足的种族和 种族社区。预计未来几年阿尔茨海默氏症患者的数量将会增加， 这增加了公共卫生系统的负担。要缓解这种情况，重要的是找到治疗方法。 通过临床试验可以减缓疾病的进展，特别是在不同的人群中。AD临床前试验 缺乏多样性，以及了解自己的生物标志物状态和需要学习伙伴才能注册的试验要求 可能会起到作用。我们的项目重点是了解这些临床前试验要求的影响， 生物标志物的披露和研究伙伴的要求，在种族和民族之间是不同的。我们将使用 认知访谈，以检验我们的假设，即种族和民族群体在学习意愿方面存在差异 生物标志物状态。我们还将使用以前开发的评估工具1，来评估对 不同群体之间的学习伙伴要求。我们认为，学习伙伴的要求是不同的 影响种族和民族群体的参与能力/意愿。这项工作将帮助我们收集数据以 在代表性不足的人群中指导AD临床前试验的招募，更好地了解对 在研究过程中披露生物标记物，并了解对研究态度的差异 合作伙伴要求，以便调查人员可以进行调整，以帮助代表不足的群体填补这一角色。

Abstract of Parent Research Project Alzheimer’s disease (AD) and related dementias (ADRD) disproportionately affect underrepresented racial and ethnic communities. The number of people with Alzheimer’s is expected to increase in the coming years, and with this an increased burden to the public health system. To alleviate this, it is important to find treatments through clinical trials that can slow disease progression, especially in diverse populations. Preclinical AD trials lack diversity, and the trial requirements of learning one’s biomarker status and needing a study partner to enroll could play a role. Our project focuses on understanding how the impact of these preclinical trial requirements, biomarker disclosure and study partner requirement, differs among racial and ethnic groups. We will use cognitive interviews to test our hypothesis that racial and ethnic groups differ in their willingness to learn biomarker status. We will also use a previously developed assessment instrument1, to assess attitudes toward the study partner requirement among diverse groups. We believe that the study partner requirement differentially affects ability/willingness to participate among racial and ethnic groups. This work will help us collect data to guide recruitment in preclinical AD trials in underrepresented groups, better understand attitudes toward biomarker disclosure during the research process and understand the differences in attitudes toward the study partner requirement so investigators can adjust to help underrepresented groups fill this role.