SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATION
神经元分化过程中的突触传递
基本信息
- 批准号:6342317
- 负责人:
- 金额:$ 29.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1991
- 资助国家:美国
- 起止时间:1991-04-01 至 2003-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The major goal of this work is to better understand the fundamental mechanisms involved in the development of signal processing by vestibular nuclei neurons, and how this excitability changes after peripheral vestibular injury. The chick tangential nucleus (lateral vestibular nucleus) will be investigated using brain slices and whole animals at embryonic and newborn ages. This nucleus was chosen due to its rather simple and well-known anatomy, including the fact that the two main neuron populations of this nucleus function in two of the vestibular reflexes. Already, there is a wealth of knowledge existing on neuron morphogenesis and synaptogenesis by the primary vestibular fibers in this system. Further, there is a high degree of plasticity in young animals and it is relatively easy to perform vestibular deafferentations in the chicken. The techniques applied will include whole-cell patch-clamp recordings in current- and voltage-clamp modes, outside-out patch recordings, pharmacology, and light and immunogold electron- microscopic immunocytochemistry. The specific aims include to characterize and quantify the voltage-gated outward potassium currents, vestibular synaptic currents, excitability, and glutamate neurotransmission in tangential nucleus neurons during development and after vestibular-nerve transection in the newborn. By applying multiple approaches to analyze the structure-function relationships of identified vestibular nuclei neurons, we will clarify the roles that different neuron classes play in vestibular signal processing. In addition, as we learn more about the basic mechanisms involved in excitability and synaptic transmission by vestibular nuclei neurons, we can apply this to improve drug treatments for central vestibular disorders resulting from disease, injury or aging.
这项工作的主要目标是更好地了解前庭核神经元信号处理的发展所涉及的基本机制,以及外周前庭损伤后这种兴奋性如何变化。 将使用胚胎和新生儿年龄的脑切片和整个动物研究鸡的切向核(前庭外侧核)。 选择这个核是因为它相当简单和众所周知的解剖结构,包括这个核的两个主要神经元群体在两个前庭反射中起作用的事实。 已经有大量的知识存在于这个系统中的初级前庭纤维的神经元形态发生和突触发生。 此外,幼年动物具有高度的可塑性,在鸡中进行前庭传入神经阻滞相对容易。 应用的技术将包括电流和电压钳模式下的全细胞膜片钳记录、外向膜片钳记录、药理学以及光和免疫金电子显微镜免疫细胞化学。 具体的目标包括表征和量化的电压门控外向钾电流,前庭突触电流,兴奋性,和谷氨酸神经传递的切向核神经元在发展过程中和前庭神经横断后的新生儿。通过应用多种方法来分析前庭核神经元的结构-功能关系,我们将阐明不同神经元类别在前庭信号处理中所起的作用。 此外,随着我们更多地了解前庭核神经元兴奋性和突触传递的基本机制,我们可以将其应用于改善由疾病,损伤或衰老引起的中枢前庭疾病的药物治疗。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Kenna D Peusner其他文献
Kenna D Peusner的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Kenna D Peusner', 18)}}的其他基金
The Peripheral Vestibular System in Congenital Vestibular Disorders
先天性前庭疾病的周围前庭系统
- 批准号:
10610409 - 财政年份:2021
- 资助金额:
$ 29.39万 - 项目类别:
The Peripheral Vestibular System in Congenital Vestibular Disorders
先天性前庭疾病的周围前庭系统
- 批准号:
10366081 - 财政年份:2021
- 资助金额:
$ 29.39万 - 项目类别:
The Peripheral Vestibular System in Congenital Vestibular Disorders
先天性前庭疾病的周围前庭系统
- 批准号:
10183006 - 财政年份:2021
- 资助金额:
$ 29.39万 - 项目类别:
Synaptic Transmission During Neuronal Differentiation
神经元分化过程中的突触传递
- 批准号:
7735748 - 财政年份:2009
- 资助金额:
$ 29.39万 - 项目类别:
Synaptic Transmission During Neuronal Differentiation
神经元分化过程中的突触传递
- 批准号:
7924218 - 财政年份:2009
- 资助金额:
$ 29.39万 - 项目类别:
SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATION
神经元分化过程中的突触传递
- 批准号:
2126169 - 财政年份:1991
- 资助金额:
$ 29.39万 - 项目类别:
SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATION
神经元分化过程中的突触传递
- 批准号:
2126168 - 财政年份:1991
- 资助金额:
$ 29.39万 - 项目类别:
相似国自然基金
Transmission 特征值及其相关逆散射问题的研究
- 批准号:11571132
- 批准年份:2015
- 资助金额:50.0 万元
- 项目类别:面上项目
相似海外基金
Bidirectional regulation of synaptic transmission during C. elegans thermotaxis behavior
线虫趋热行为过程中突触传递的双向调节
- 批准号:
17K07499 - 财政年份:2017
- 资助金额:
$ 29.39万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Research in the excitatory synaptic transmission during critical period of feeding
摄食关键期兴奋性突触传递研究
- 批准号:
16K11488 - 财政年份:2016
- 资助金额:
$ 29.39万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Lipid and protein resorting and recycling during synaptic transmission (A17*)
突触传递过程中脂质和蛋白质的回收和再循环 (A17*)
- 批准号:
200691785 - 财政年份:2011
- 资助金额:
$ 29.39万 - 项目类别:
Collaborative Research Centres
Mechanisms compromising GABAergic synaptic transmission during status epiletpicus
癫痫持续状态期间损害 GABA 能突触传递的机制
- 批准号:
8514739 - 财政年份:2009
- 资助金额:
$ 29.39万 - 项目类别:
Synaptic Transmission During Neuronal Differentiation
神经元分化过程中的突触传递
- 批准号:
7735748 - 财政年份:2009
- 资助金额:
$ 29.39万 - 项目类别:
Synaptic Transmission During Neuronal Differentiation
神经元分化过程中的突触传递
- 批准号:
7924218 - 财政年份:2009
- 资助金额:
$ 29.39万 - 项目类别:
Mechanisms compromising GABAergic synaptic transmission during status epiletpicus
癫痫持续状态期间损害 GABA 能突触传递的机制
- 批准号:
8122114 - 财政年份:2009
- 资助金额:
$ 29.39万 - 项目类别:
Mechanisms compromising GABAergic synaptic transmission during status epiletpicus
癫痫持续状态期间损害 GABA 能突触传递的机制
- 批准号:
7767948 - 财政年份:2009
- 资助金额:
$ 29.39万 - 项目类别:
Mechanisms compromising GABAergic synaptic transmission during status epiletpicus
癫痫持续状态期间损害 GABA 能突触传递的机制
- 批准号:
8316287 - 财政年份:2009
- 资助金额:
$ 29.39万 - 项目类别:
CALCIUM-MEDIATED EXOCYTOSIS OF NEUROTRANSMITTER DURING SYNAPTIC TRANSMISSION
突触传递过程中钙介导的神经递质胞吐作用
- 批准号:
7722315 - 财政年份:2008
- 资助金额:
$ 29.39万 - 项目类别: